Results 191 to 200 of about 2,987,022 (341)

Materialistic and theistic perspectives on the origin of life

, 2022
Fazale R. Rana, Fazale R. Rana
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Did organs precede organisms in the origin of life? [PDF]

Microlife
Baquero F, Bever GS, de Lorenzo V, Fernández-Lanza V, Briones C.   +4 more
europepmc   +1 more source

The Legend of ATP: From Origin of Life to Precision Medicine. [PDF]

Metabolites, 2022
Chu XY, Xu YY, Tong XY, Wang G, Zhang HY.   +4 more
europepmc   +1 more source

Origin and Evolution of Life: Another Study Program.

, 1999
Yuzuru Husimi
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Oxidative stress in pediatric diseases associated with the origin of life and growth and development. [PDF]

Front Cell Dev Biol
Zheng B, Fu J.
europepmc   +1 more source

RNA enigma: "From origin of life to novel Coronavirus-COVID-19". [PDF]

Saudi J Biol Sci, 2022
Krishnaveni M, Venkatesh S.
europepmc   +1 more source

Energy and Semiotics: The Second Law and the Origin of Life

, 2005
Stanley N. Salthe
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source