Results 71 to 80 of about 860,302 (306)

Bioenergetics and Life's Origins [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2010
Bioenergetics is central to our understanding of living systems, yet has attracted relatively little attention in origins of life research. This article focuses on energy resources available to drive primitive metabolism and the synthesis of polymers that could be incorporated into molecular systems having properties associated with the living state ...
David, Deamer, Arthur L, Weber
openaire   +2 more sources

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier   +10 more
wiley   +1 more source

Self-similar patterns from abiotic decarboxylation metabolism through chemically oscillating reactions: A prebiotic model for the origin of life [PDF]

open access: yes, 2023
The origin of life must have included an abiotic stage of carbon redox reactions that involved electron transport chains and the production of lifelike patterns.
Kevin Devine   +6 more
core   +1 more source

Defining Lyfe in the Universe: From Three Privileged Functions to Four Pillars

open access: yesLife, 2020
Motivated by the need to paint a more general picture of what life is—and could be—with respect to the rest of the phenomena of the universe, we propose a new vocabulary for astrobiological research.
Stuart Bartlett, Michael L. Wong
doaj   +1 more source

Distribution of Trichinella spiralis, Trichinella britovi, and Trichinella pseudospiralis in the Diaphragms and T. spiralis and T. britovi in the Tongues of Experimentally Infected Pigs

open access: yesFrontiers in Veterinary Science, 2021
There is little or even no data in the global literature on the distribution of different species of Trichinella in the individual parts of the diaphragms and tongues in infected pigs.
Michał Gondek   +5 more
doaj   +1 more source

Thermodynamics and the origin of life

open access: yesCanadian Journal of Physics, 2022
Modern developments in nonequilibrium thermodynamics have significant implications for the origins of life. The reasons for this are closely related to a generalized version of the second law of thermodynamics recently found for entropy production during irreversible evolution of a given system such as self-replicating RNA.
openaire   +2 more sources

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar   +7 more
wiley   +1 more source

Heavy Metals as a Factor Increasing the Functional Genetic Potential of Bacterial Community for Polycyclic Aromatic Hydrocarbon Biodegradation

open access: yesMolecules, 2020
The bioremediation of areas contaminated with hydrocarbon compounds and heavy metals is challenging due to the synergistic toxic effects of these contaminants.
Justyna Staninska-Pięta   +6 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot   +6 more
wiley   +1 more source

Origins of Life Research: The Conundrum between Laboratory and Field Simulations of Messy Environments [PDF]

open access: yes, 2022
Most experimental results that guide research related to the origin of life are from laboratory simulations of the early Earth conditions. In the laboratory, emphasis is placed on the purity of reagents and carefully controlled conditions, so there is a ...
David Deamer, Deamer, David
core   +1 more source

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