Nucleosomes influence multiple steps during replication initiation [PDF]
eLife, 2017 Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation.
Ishara F Azmi +7 more
doaj +5 more sources
Identification of the Unwinding Region in the Clostridioides difficile Chromosomal Origin of Replication [PDF]
Frontiers in Microbiology, 2020 Faithful DNA replication is crucial for viability of cells across all kingdoms. Targeting DNA replication is a viable strategy for inhibition of bacterial pathogens.
Ana M. Oliveira Paiva +6 more
doaj +2 more sources
The replication machinery of LUCA: common origin of DNA replication and transcription
BMC Biology, 2020 Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of
Eugene V. Koonin +3 more
doaj +2 more sources
Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe. [PDF]
Genome Biol, 2015 Background DNA replication initiates on defined genome sites, termed origins. Origin usage appears to follow common rules in the eukaryotic organisms examined to date: all chromosomes are replicated from multiple origins, which display variations in ...
Marques CA +4 more
europepmc +4 more sources
E2 protein is the major determinant of specificity at the human papillomavirus origin of replication. [PDF]
PLoS ONE, 2019 The replication of human papillomavirus (HPV) genomes requires E1 and E2 proteins as the viral trans-factors and the replication origin, located in the URR, as a cis-element.
Airiin Laaneväli +3 more
doaj +2 more sources
Genome Replication in Thermococcus kodakarensis Independent of Cdc6 and an Origin of Replication [PDF]
Frontiers in Microbiology, 2017 The initiation of DNA replication is typically tightly regulated by proteins that form initiation complexes at specific sequences known as replication origins.
Alexandra M. Gehring +7 more
doaj +2 more sources
Functional characterization of the origin of replication of pRN1 from Sulfolobus islandicus REN1H1. [PDF]
PLoS ONE, 2013 Plasmid pRN1 from Sulfolobus islandicus REN1H1 is believed to replicate by a rolling circle mechanism but its origin and mechanism of replication are not well understood.
Chijioke J Joshua +2 more
doaj +2 more sources
DNA replication origins in archaea [PDF]
Frontiers in Microbiology, 2014 DNA replication initiation, which starts at specific chromosomal site (known as replication origins), is the key regulatory stage of chromosome replication.
Zhenfang eWu +5 more
doaj +3 more sources
The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. [PDF]
PLoS Pathogens, 2016 The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome in infected cells. To initiate its
Marsha DeSmet +5 more
doaj +5 more sources
The replication origin of a repABC plasmid [PDF]
BMC Microbiology, 2011 Background repABC operons are present on large, low copy-number plasmids and on some secondary chromosomes in at least 19 α-proteobacterial genera, and are responsible for the replication and segregation properties of these replicons.
Cevallos Miguel A +3 more
doaj +3 more sources