Results 41 to 50 of about 598,816 (344)
Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]
, 2010 Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G +5 more
core +2 more sources
Molecules and Cells, 2017 Summary The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How this is accomplished is still poorly understood. Using purified yeast replication proteins and fully chromatinized templates, we have reconstituted this ...
Christoph F. Kurat +4 more
semanticscholar +1 more source
The origin of replicators and reproducers [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2006 Replicators are fundamental to the origin of life and evolvability. Their survival depends on the accuracy of replication and the efficiency of growth relative to spontaneous decay. Infrabiological systems are built of two coupled autocatalytic systems, in contrast to minimal living systems that must comprise at least a metabolic subsystem, a ...
openaire +2 more sources
Mechanism of DNA Recognition at a Viral Replication Origin [PDF]
, 2006 Recognition of the DNA origin by the Epstein-Barr nuclear antigen 1 (EBNA1) protein is the primary event in latentphase genome replication of the Epstein-Barr virus, a model for replication initiation in eukaryotes.
de Prat Gay, Gonzalo +3 more
core +1 more source
The level of origin firing inversely affects the rate of replication fork progression
Journal of Cell Biology, 2013 Cells with reduced origin firing have an increased rate of replication fork progression, whereas fork progression is slowed in cells with excess origins.
Yuan Zhong +11 more
semanticscholar +1 more source
Concurrent Replication and Methylation at Mammalian Origins of Replication [PDF]
Molecular and Cellular Biology, 1998 Observations made with Escherichia coli have suggested that a lag between replication and methylation regulates initiation of replication. To address the question of whether a similar mechanism operates in mammalian cells, we have determined the temporal relationship between initiation of replication and methylation in mammalian cells both at a ...
F D, Araujo +4 more
openaire +2 more sources
Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex [PDF]
, 1998 The Xenopus origin recognition complex is essential for chromosomal DNA replication in cell-free extracts. We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies and analyzed its composition and properties.
Carpenter, Phillip B. +1 more
core +1 more source
Replication control: Choreographing replication origins [PDF]
Current Biology, 1998 Budding yeast replication origins are activated during S phase according to a predetermined temporal programme. Two recent studies indicate that this programme is executed, at least in part, by the S-phase-promoting cyclins that act to assemble a pre-initiation complex which includes the Cdc45 protein.
openaire +2 more sources
Universal temporal profile of replication origin activation in eukaryotes. [PDF]
PLoS ONE, 2009 Although replication proteins are conserved among eukaryotes, the sequence requirements for replication initiation differ between species. In all species, however, replication origins fire asynchronously throughout S phase. The temporal program of origin
Arach Goldar +2 more
doaj +1 more source
EMBO Reports, 2017 The human RIF1 protein controls DNA replication, but the molecular mechanism is largely unknown. Here, we demonstrate that human RIF1 negatively regulates DNA replication by forming a complex with protein phosphatase 1 (PP1) that limits phosphorylation ...
S. Hiraga +9 more
semanticscholar +1 more source