Results 91 to 100 of about 598,816 (344)

Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication.

PLoS ONE, 2012
Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified.
Tamara Evans Braun, Emma Poole, John Sinclair   +2 more
doaj   +1 more source

Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding [PDF]

, 2016
Repression of the cellular CIITA gene is part of the immune evasion strategy of the γherpes virus Epstein-Barr virus (EBV) during its lytic replication cycle in B-cells. In part this is mediated through down regulation of MHC class II gene expression via
Adamson, Alison J. Sinclair, Broderick, Crawford, Farrell, Holley-Guthrie, Kay Osborn, Kenney, Kenney, Klug, Mikaélian, Nicolae Balan, Packham, Sinclair, Young   +14 more
core   +1 more source

Rif1 is a global regulator of timing of replication origin firing in fission yeast.

Genes & Development, 2012
One of the long-standing questions in eukaryotic DNA replication is the mechanisms that determine where and when a particular segment of the genome is replicated.
Motoshi Hayano, Yutaka Kanoh, S. Matsumoto, Claire Renard-Guillet, K. Shirahige, H. Masai   +5 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. [PDF]

PLoS Genetics, 2013
Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard ...
Elizabeth X Kwan, Eric J Foss, Scott Tsuchiyama, Gina M Alvino, Leonid Kruglyak, Matt Kaeberlein, M K Raghuraman, Bonita J Brewer, Brian K Kennedy, Antonio Bedalov   +9 more
doaj   +1 more source

The Role of Transcription in the Activation of a Drosophila Amplification Origin [PDF]

, 2014
The mechanisms that underlie metazoan DNA replication initiation, especially the connection between transcription and replication origin activation, are not well understood. To probe the role of transcription in origin activation, we exploited a specific
Hua, Brian, Li, Sharon, Orr-Weaver, Terry L.   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A new class of disordered elements controls DNA replication through initiator self-assembly

eLife, 2019
The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin.
Matthew W Parker, Maren Bell, Mustafa Mir, Jonchee A Kao, Xavier Darzacq, Michael R Botchan, James M Berger   +6 more
doaj   +1 more source

Intrachromosomal recombination mediated by the polyomavirus large T antigen [PDF]

, 1995
We used a spleen necrosis virus-based retroviral vector to introduce the polyomavirus replication origin into rat cells and developed a system to analyze homologous recombination events that do not reconstitute a selectable marker.
Alt, Asselin, Bastin, Bird, Botchan, Bouchard, Bouchard, Bouchard, Cegielska, Colantuoni, Dornreiter, Dougherty, Hirt, Israel, Land, Larose, Liskay, Miller, Pall, Pellegrini, Roberge, Scheidtmann, Scheidtmann, Schimke, Shah, Southern, Spradling, St-Onge, St-Onge, St-Once, St-Onge, Thomas, Tlsty, Varshavski, Wang, Watanabe   +35 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source