Results 231 to 240 of about 569,837 (343)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Identification of the minimal replicon and the origin of replication of the crenarchaeal plasmid pRN1. [PDF]

Microbiologyopen, 2014
Berkner S, Hinojosa MP, Prangishvili D, Lipps G.   +3 more
europepmc   +1 more source

Replication Data for: Institutional Transformation and the Origins of World Income Distribution

, 2018
Rok Spruk
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Srcap Chromatin Remodeler Is Required for Efficient Replication Dynamics in Mammalian Cells. [PDF]

Int J Mol Sci
Dzhokova SK, Hristova RH, Botev PS, Guecheva TN, Gospodinov AG.   +4 more
europepmc   +1 more source

Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae [PDF]

, 2014
Ignacio Soriano, Esther Cabañas Morafraile, Enrique Vázquez, Francisco Antequera, Mónica Segurado   +4 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Termination of DNA replication drives genomic instability via multiple mechanisms. [PDF]

Nucleic Acids Res
Goodall DJ, Dimude JU, Hashemloo MA, Dunbar EL, Grigoryan I, Upton AL, Bolt EL, Rudolph CJ.   +7 more
europepmc   +1 more source

Binding and bending of the lambda replication origin by the phage O protein. [PDF]

, 1985
Kenneth Zahn, F. R. Blattner
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source