Results 271 to 280 of about 598,816 (344)

Artificial Intelligence‐based Online Symptom Assessment Tools for Systemic Lupus Erythematosus (SLE) diagnosis: Patient Perspectives

Arthritis Care &Research, Accepted Article.
Objective The objective of this article is to identify perceptions of SLE patients regarding artificial intelligence (AI)‐based online symptom assessment tools, and the potential of these tools to address diagnostic barriers. Methods Adults from our SLE research cohort were invited to participate in 60‐90 minute virtual focus groups concerning their ...
Olivia A. Stein, Jennifer LF. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source

Initial sites of SIV rebound after antiretroviral treatment cessation in rhesus macaques. [PDF]

Nat Microbiol
Keele BF, Okoye AA, Immonen TT, Varco-Merth B, Duell D, Nkoy C, Goodwin W, Hoffmeister S, Hughes CM, Kose E, Conchas A, Goodman CA, Fennessey CM, Macairan A, Bosche WJ, Fast R, Homick CM, Hull M, Oswald K, Shoemaker R, Silipino L, Welker JL, Smedley J, Labriola CS, Axthelm MK, Hansen SG, Estes JD, Barouch DH, Lifson JD, Picker LJ.   +29 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

KCTD10 as a selective cancer dependency from transcription-replication conflicts (TRCs). [PDF]

Ageing Cancer Res Treat
Kloeber JA, Chen B, Mutter R, Huang J, Lou Z.   +4 more
europepmc   +1 more source

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

Advanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi, Pasquale Guglielmi, Gianfranco Palumbo, Giuseppe Carbone   +3 more
wiley   +1 more source

Unusual replication dynamics during Plasmodium falciparum schizogony. [PDF]

Malar J
Berners-Lee R, Smith TK.
europepmc   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

A new family of rolling-circle replication endonucleases widespread in archaeal viruses and plasmids. [PDF]

Nucleic Acids Res
Wang Y, Duan Z, Chen Z, Li S, Chen H, Chen J, Wang Y, Wang J, An K, Xiang J, Du S, Liu Y, Krupovic M, Chen X.   +13 more
europepmc   +1 more source

Synthesis of a Novel Thermoresponsive S53P4 Bioactive Glass Extract–Poloxamer 407 Injectable Hydrogels: Assessment of Biocompatibility and Antimicrobial Properties

Advanced Engineering Materials, EarlyView.
This study investigates innovative thermoreversible hydrogels derived from S53P4 bioactive glass extracts to aid in the healing of infected diabetic foot wounds. These injectable gels, which gel at body temperature, release beneficial ions and remain stable over time.
Marian G. Vargas Guerrero, Adrian Stiller, Alex Nygård, Matej Krivulka, Lars Galema, Erwin Peters, Jimmy Lucchesi, Peter Uppstu, Leena Hupa, Jacobus J. C. Arts   +9 more
wiley   +1 more source

Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae. [PDF]

PLoS Genet
de La Roche Saint-André C.
europepmc   +1 more source