Results 81 to 90 of about 14,422 (161)

Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study

Vaccines
Background: Annual influenza vaccine updates target viral drift, but immune responses may be biased by original antigenic sin (OAS). Few studies have explored this across closely related strains. This study examines how OAS shapes responses to sequential
Mónica Espinar-García, Isabel María Vallejo-Bermúdez, María Ángeles Onieva-García, Irene Reina-Alfonso, Luis Llapa-Chino, Pablo Álvarez-Heredia, Inmaculada Salcedo, Rafael Solana, Alejandra Pera, Alexander Batista-Duharte   +9 more
doaj   +1 more source

Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus [PDF]

, 2006
Background Antigenic diversity in dengue virus strains has been studied, but large-scale and detailed systematic analyses have not been reported. In this study, we report a bioinformatics method for analyzing viral antigenic diversity in the context of T-
Khan, M., Heiny, T., Lee, K.X., Srinivasan, N., Tan,, August, J.T., Brusic, V   +6 more
core   +2 more sources

Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China [PDF]

, 2012
A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response.
Cummings, DAT, Guan, Y, Jiang, CQ, Lessler, J, Read, JM, Riley, S, Smith, GJD, Wang, S, Zhu, H   +8 more
core   +3 more sources

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Viruses, 2019
Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes.
Maria Malm, Timo Vesikari, Vesna Blazevic   +2 more
doaj   +1 more source

Does Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?

BMC Infectious Diseases, 2010
Background A pandemic novel H1N1 swine-origin influenza virus has emerged. Most recently the World Health Organization has announced that in a country-dependent fashion, up to 15% of cases may require hospitalization, often including respiratory support.
Nishiura Hiroshi, Chowell Gerardo, Reichert Tom, Christensen Ronald A, McCullers Jonathan A   +4 more
doaj   +1 more source

Prevalence and Predictors for Homo- and Heterosubtypic Antibodies Against Influenza A Virus [PDF]

, 2017
Heterosubtypic antibodies to influenza A virus will be crucial for the development of a pan-influenza vaccine. Here we show that most individuals already possess heterosubtypic antibodies and that their generation is favored both by vaccination and ...
Bianchi, Matteo, Günthard, Huldrych F., Hangartner, Lars, Kohler, Ines, Ledergerber, Bruno, Scherrer, Alexandra U., Steck, Marco, Wyrzucki, Arkadiusz, Zagordi, Osvaldo   +8 more
core  

Potential immune evasion of the severe acute respiratory syndrome coronavirus 2 Omicron variants

Frontiers in Immunology
Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic.
Luyi Chen, Ying He, Hongye Liu, Yongjun Shang, Guoning Guo   +4 more
doaj   +1 more source

Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection

Pathogens, 2019
When influenza A virus infects an immune individual, preexisting memory B cell (MBC) activation and rapid anamnestic antibody production plays a key role in viral clearance.
Mark Y. Sangster, Phuong Q. T. Nguyen, David J. Topham   +2 more
doaj   +1 more source

Influenza virus antigenic variation, host antibody production and new approach to control epidemics

, 2016
Influenza is an infectious disease and can lead to life-threatening complications like pneumonia. The disease is caused by three types of RNA viruses called influenza types A, B and C, each consisting of eight negative single-stranded RNA-segments ...
Chen, Jinglong, Deng, Yi-Mo
core   +1 more source

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]

, 2003
CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub, Brander, Christian, Harlow, Jason D, Kalams, Spyros A, Sarkis, Phuong Thi Nguyen, Walker, Bruce D, Yang, Otto O   +6 more
core