Results 91 to 100 of about 4,761,340 (218)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Investigating original antigenic sin responses to H5N1 influenza viruses

, 2010
H5N1 influenza A virus remains a global threat since its outbreak in 1997. Its re-emergence in 2003 spread from Asia to Europe, the Middle-East and Africa, raising concerns of a possible pandemic.
Masseoud, Feda, Temperton, Nigel J., Jacob, Joshy, Skountzou, Ioanna   +3 more
core  

Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein [PDF]

, 1992
Computer simulation of the conformations of short antigenic peptides (&lo residues) either free or bound to their receptor, the major histocompatibility complex (MHC)- encoded glycoprotein H-2 Ld, was employed to explain experimentally determined ...
Reddehase, Matthias J., Rognan, Didier, Koszinowski, Ulrich H., Folkers, Gerd, Gerd Folkers, Didier Rognan, Matthias J. Reddehase, Ulrich H. Koszinowski   +7 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Viruses, 2019
Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes.
Maria Malm, Timo Vesikari, Vesna Blazevic   +2 more
doaj   +1 more source

How "Original Sin" was Overcome: The Evolution of External Debt Denominated in Domestic Currencies in the United States and the British Dominions [PDF]

This paper examines the historical origins of "Original Sin" or why countries are unable to issue long term debt domestically or borrow abroad in terms of the domestic currency.
Michael D. Bordo, Angela Redish, Christopher Meissner   +2 more
core  

Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus [PDF]

, 2010
Identifying when past exposure to an infectious disease will protect against newly emerging strains is central to understanding the spread and the severity of epidemics, but the prediction of viral cross-protection remains an important unsolved problem ...
Reeve Richard, de Beer, T.A.P., Hester G O'Neill, Daniel T Haydon, O'Neill, H.G., Matthews, L., Opperman, Pamela, Belinda Blignaut, Esterhuysen, Jan J., Richard Reeve, Maree, F.F., Hester G. O'Neill, Tjaart A P de Beer, Haydon, Daniel Thomas, De Beer, Tjaart, Maree, Francois Frederick, Tjaart A. P. de Beer, Maree Francois F., Jacques Theron, Reeve, R., O'Neill Hester G., Opperman, Pamela Anne, Rieder, Elizabeth, Theron, Jacques, Elizabeth Rieder, Haydon, D.T., Blignaut Belinda, Blignaut, B., Matthews Louise, Rieder Elizabeth, Theron, J., Maree, Francois, Haydon Daniel T., Blignaut, Belinda, Opperman, P., Vosloo, W., Louise Matthews, Reeve, Richard, Elizabeth E. Fry, O'Neill, Hester Gertruida, de Beer Tjaart A. P., Pamela Opperman, Jan J. Esterhuysen, Francois F Maree, Haydon, Daniel, Fry, E.E., Elizabeth E Fry, Wilna Vosloo, Fry, Elizabeth E., Vosloo, Wilna, Vosloo Wilna, Daniel T. Haydon, O’Neill, Hester G., Esterhuysen, J.J., Opperman Pamela, Matthews, Louise, De Beer, T.A.P. (Tjaart Andries Petrus), Esterhuysen Jan J., Esterhuysen, Jan, Francois F. Maree, Theron Jacques, Rieder, E., Jan J Esterhuysen, Fry Elizabeth E., Fry, Elizabeth   +64 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Potential immune evasion of the severe acute respiratory syndrome coronavirus 2 Omicron variants

Frontiers in Immunology
Coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic.
Luyi Chen, Ying He, Hongye Liu, Yongjun Shang, Guoning Guo   +4 more
doaj   +1 more source