Results 1 to 10 of about 443 (202)

Immune Imprinting and Implications for COVID-19

Vaccines, 2023
Immunological memory is the key source of protective immunity against pathogens. At the current stage of the COVID-19 pandemic, heterologous combinations of exposure to viral antigens during infection and/or vaccination shape a distinctive immunological ...
Zhiqian Zhou, Julia Barrett, Xuan He
doaj   +5 more sources

Immune imprinting of SARS-CoV-2 responses: changing first immune impressions

mSphere
Since the emergence of the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and the successful rollout of protective vaccines based on this original strain, SARS-CoV-2 has evolved into several variants, in a classical virus ...
J. Torresi, M. A. Edeling
doaj   +5 more sources

First Impressions Matter: Immune Imprinting and Antibody Cross-Reactivity in Influenza and SARS-CoV-2

Pathogens, 2023
Many rigorous studies have shown that early childhood infections leave a lasting imprint on the immune system. The understanding of this phenomenon has expanded significantly since 1960, when Dr.
Samantha M. King, Shane P. Bryan, Shannon P. Hilchey, Jiong Wang, Martin S. Zand   +4 more
doaj   +3 more sources

Immune imprinting: The persisting influence of the first antigenic encounter with rapidly evolving viruses

Human Vaccines & Immunotherapeutics
Immune imprinting is a phenomenon that stems from the fundamentals of immunological memory. Upon recurrent exposures to an evolving pathogen, the immune system must weigh the benefits of rapidly recalling established antibody repertoires with greater ...
Mariam Maltseva, Alexa Keeshan, Curtis Cooper, Marc-André Langlois   +3 more
doaj   +3 more sources

Effect of seasonal coronavirus immune imprinting on the immunogenicity of inactivated COVID-19 vaccination

Frontiers in Immunology, 2023
BackgroundPre-existing cross-reactive immunity among different coronaviruses, also termed immune imprinting, may have a comprehensive impact on subsequent SARS-CoV-2 infection and COVID-19 vaccination effectiveness.
Di Yin, Di Yin, Zirong Han, Zirong Han, Bing Lang, Bing Lang, Yanjun Li, Guoqin Mai, Guoqin Mai, Hongbiao Chen, Liqiang Feng, Yao-qing Chen, Yao-qing Chen, Huanle Luo, Huanle Luo, Yaming Xiong, Lin Jing, Xiangjun Du, Xiangjun Du, Xiangjun Du, Yuelong Shu, Yuelong Shu, Yuelong Shu, Caijun Sun, Caijun Sun, Caijun Sun   +25 more
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Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

Emerging Microbes and Infections
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRNA vaccines, a ...
Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Ran An, Yao Wang, Jing Wang, Haiyan Sun, Peng Wang, Lingling Yu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Yunlong Cao   +17 more
doaj   +3 more sources

Factors determining the outcomes of immune imprinting after repeated orthoflavivirus infections

Frontiers in Immunology
Orthoflaviviruses, a group of arthropod-borne viruses, represent a significant global health threat, with hundreds of millions of infections each year, often leading to severe clinical outcomes.
Gielenny M. Salem, Fan-Chi Chen, James J. Cai, Day-Yu Chao, Day-Yu Chao, Day-Yu Chao   +5 more
doaj   +3 more sources

Infant Antibody Repertoires during the First Two Years of Influenza Vaccination

mBio, 2022
The first encounter with influenza virus biases later immune responses. This “immune imprinting,” formerly from infection within a few years of birth, is in the United States now largely from immunization with a quadrivalent, split vaccine (IIV4 ...
Masayuki Kuraoka, Nicholas C. Curtis, Akiko Watanabe, Hidetaka Tanno, Seungmin Shin, Kevin Ye, Elizabeth Macdonald, Olivia Lavidor, Susan Kong, Tarra Von Holle, Ian Windsor, Gregory C. Ippolito, George Georgiou, Emmanuel B. Walter, Garnett Kelsoe, Stephen C. Harrison, M. Anthony Moody, Goran Bajic, Jiwon Lee   +18 more
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Omicron (B.1.1.529) BA.1 or BA.2-related effects on immune responses in previously naïve versus imprinted individuals: immune imprinting as an advantage in the humoral immune response against novel variants

Frontiers in Immunology, 2023
BackgroundImmune imprinting is a phenomenon in which a person's immune system develops a specific immunological memory of the pathogen or vaccine due to a previous exposure.
Sissy Therese Sonnleitner, Sissy Therese Sonnleitner, Samira Walder, Ludwig Knabl, Ludwig Knabl, Roswitha Poernbacher, Thomas Tschurtschenthaler, Eva Hinterbichler, Stefanie Sonnleitner, Viktoria Muehlmann, Wilfried Posch, Gernot Walder, Gernot Walder   +12 more
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Five doses of the mRNA vaccination potentially suppress ancestral-strain stimulated SARS-CoV2-specific cellular immunity: a cohort study from the Fukushima vaccination community survey, Japan

Frontiers in Immunology, 2023
The bivalent mRNA vaccine is recommended to address coronavirus disease variants, with additional doses suggested for high-risk groups. However, the effectiveness, optimal frequency, and number of doses remain uncertain.
Yuta Tani, Morihito Takita, Morihito Takita, Masatoshi Wakui, Hiroaki Saito, Hiroaki Saito, Takamitsu Nishiuchi, Tianchen Zhao, Chika Yamamoto, Takeshi Kawamura, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Yudai Kaneko, Tatsuhiko Kodama, Ryuzaburo Shinaha, Masaharu Tsubokura, Masaharu Tsubokura, Masaharu Tsubokura   +19 more
doaj   +1 more source