Results 11 to 20 of about 443 (202)
Immune Imprinting in the Influenza Ferret Model [PDF]
Vaccines, 2020 The initial exposure to influenza virus usually occurs during childhood. This imprinting has long-lasting effects on the immune responses to subsequent infections and vaccinations.
Amanda L. Skarlupka, Ted M. Ross
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Immune Imprinting Drives Human Norovirus Potential for Global Spread
mBio, 2022 Understanding the complex interactions between virus and host that drive new strain evolution is key to predicting the emergence potential of variants and informing vaccine development. Under our hypothesis, future dominant human norovirus GII.4 variants
Lisa C. Lindesmith +21 more
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“Structural imprinting” of the cutaneous immune effector function [PDF]
Tissue Barriers, 2020 Keratinization provides tolerance to desiccation and mechanical durability. Loricrin, which is an epidermal thiol-rich protein, efficiently stabilizes terminally differentiated keratinocytes and maintains redox homeostasis. The discovery of the largely asymptomatic loricrin knockout (LKO) phenotype decades ago was rather unpredicted. Nevertheless, when
Yosuke Ishitsuka +2 more
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Nature Communications, 2023 The heterogeneity of the SARS-CoV-2 immune responses has become considerably more complex over time and diverse immune imprinting is observed in vaccinated individuals. Despite vaccination, following the emergence of the Omicron variant, some individuals
Laura Pérez-Alós +18 more
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Immune interference in effectiveness of influenza and COVID-19 vaccination
Frontiers in Immunology, 2023 Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2.
Yiwen Xie +9 more
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Imprinting of the immune system by the microbiota early in life [PDF]
Mucosal Immunology, 2020 The ontogeny and maturation of the immune system is modulated by the microbiota. During fetal life, the mother's microbiota produces compounds that are transferred to the fetus and offspring, and enhance the generation of innate immune cells. After birth, the colonizing microbiota induces the development of intestinal lymphoid tissues and maturation of
Ziad, Al Nabhani, Gérard, Eberl
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The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?
Vaccines, 2020 Influenza virus infection causes severe respiratory illness in people worldwide, disproportionately affecting infants. The immature respiratory tract coupled with the developing immune system, and lack of previous exposure to the virus is thought to ...
Melissa Rioux +6 more
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Immune imprinting and SARS-CoV-2 vaccine design [PDF]
Trends in Immunology, 2021 Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain.
Adam K. Wheatley +6 more
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Immune imprinting and next-generation coronavirus vaccines
Nature Microbiology, 2023 Vaccines based on historical virus isolates provide limited protection from continuously evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill over between animals and humans. Despite repeated booster immunizations, population-wide declines in the neutralization of severe acute respiratory syndrome coronavirus 2 ...
Huang, Chloe Qingzhou +4 more
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