Results 21 to 30 of about 443 (202)
Frontiers in Immunology, 2022 Since the emergence of SARS-CoV-2 (SARS-2), multiple vaccine candidates were developed and studied both preclinically and clinically. Nearly all are based on the SARS-2 spike glycoprotein or its receptor binding domain (RBD).
Blake M. Hauser +7 more
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Vaccines, 2020 Changes in innate and adaptive immune responses caused by viral imprinting can have a significant direct or indirect influence on secondary infections and vaccine responses.
Ermias Jirru +5 more
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Repeated influenza vaccination provides cumulative protection from distinct H3N2 viruses
Clinical & Translational Immunology, 2021 Objectives Current inactivated influenza vaccines provide suboptimal protection against antigenic drift, and repeated annual vaccinations shape antibody specificity but the effect on protection from infection is not well understood.
Niloufar Kavian +3 more
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Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous Immunization
Viruses, 2022 Antigenic imprinting, which describes the bias of the antibody response due to previous immune history, can influence vaccine effectiveness. While this phenomenon has been reported for viruses such as influenza, there is little understanding of how prior
Huibin Lv +11 more
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Neutralization, effector function and immune imprinting of Omicron variants
Nature, 2023 AbstractCurrently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain1 (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of vaccines and therapies remains poorly understood.
Amin Addetia +64 more
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Immune imprinting as a barrier to effective COVID-19 vaccines
Cell Reports Medicine, 2023 Wang and colleagues show that immune imprinting impairs neutralizing antibody titers for bivalent mRNA vaccination against SARS-CoV-2 Omicron subvariants. Imprinting from three doses of monovalent vaccine can be alleviated by BA.5 or BQ-lineage breakthrough infection but not by a bivalent booster.1.
Faraone, Julia N., Liu, Shan-Lu
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Frontiers in Immunology, 2022 Defining immune correlates of disease severity is important to better understand the immunopathogenesis in COVID-19. Here we made use of a protein microarray platform to detect IgG- and IgA-reactive antibodies in sera and saliva respectively, and assess ...
Wouter L. Smit +15 more
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A Complementary Union of SARS-CoV2 Natural and Vaccine Induced Immune Responses
Frontiers in Immunology, 2022 Our understanding of the immune responses that follow SARS-CoV-2 infection and vaccination has progressed considerably since the COVID-19 pandemic was first declared on the 11th of March in 2020. Recovery from infection is associated with the development
Joseph Torresi +4 more
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Viruses, 2019 The influenza virus-host interaction is a classic arms race. The recurrent and evolving nature of the influenza virus family allows a single host to be infected several times.
Magen Ellen Francis +2 more
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Vaccines, 2020 (1) Background: The influenza virus continues to cause significant annual morbidity and mortality. The overall efficacy of seasonal influenza vaccination is suboptimal, which is partly due to host immune factors.
Amy C. Sherman +9 more
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