Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really “Sinful”? [PDF]
Viruses, 2023 The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Tal Einav +5 more
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Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19 [PDF]
mSphere, 2021 The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing
Eric L. Brown, Heather T. Essigmann
doaj +4 more sources
Original Antigenic Sin and Respiratory Syncytial Virus Vaccines [PDF]
Vaccines, 2019 The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of ...
Ralph A. Tripp, Ultan F. Power
doaj +4 more sources
Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants [PDF]
MedCommOriginal antigenic sin (OAS), or immune imprinting, triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ancestral (WT) strain vaccine, or infection, has led to weakened neutralizing antibody response against Omicron variant like BA ...
Guangxu Zhang +15 more
doaj +3 more sources
Inactivated COVID-19 vaccines: potential concerns of antibody-dependent enhancement and original antigenic sin [PDF]
Immunology Letters, 2023 Inactivated vaccine is one of the platforms employed in COVID-19 vaccines. Inactivated vaccines have been associated with concerns of antibody-dependent enhancement (ADE) and original antigenic sin (OAS), which are related to non-neutralising or poorly ...
Philip H Li, Andy Ka Chun Kan
exaly +3 more sources
Factors determining the outcomes of immune imprinting after repeated orthoflavivirus infections [PDF]
Frontiers in ImmunologyOrthoflaviviruses, a group of arthropod-borne viruses, represent a significant global health threat, with hundreds of millions of infections each year, often leading to severe clinical outcomes.
Gielenny M. Salem +5 more
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Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study [PDF]
VaccinesBackground: Annual influenza vaccine updates target viral drift, but immune responses may be biased by original antigenic sin (OAS). Few studies have explored this across closely related strains. This study examines how OAS shapes responses to sequential
Mónica Espinar-García +9 more
doaj +2 more sources
Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection [PDF]
Infectious Diseases & Immunity. Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections.
Miao Wang +4 more
doaj +2 more sources
Innate immunity and training to subvert original antigenic sin by the humoral immune response [PDF]
eLifeOriginally defined in the context of influenza vaccines by Thomas Francis Jr. in the late 1950s, original antigenic sin (OAS) refers to the tendency of the immune system to preferentially recall B cell memory against primary antigen after secondary ...
Faez Amokrane Nait Mohamed +1 more
doaj +2 more sources
SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein Antibody Response in SARS-CoV-2 Infection [PDF]
Journal of Immunology Research, 2022 Immune imprinting or original antigenic sin (OAS) is the process by which the humoral memory response to an antigen can inhibit the response to new epitopes of that antigen originating from a second encounter with the pathogen. Given the situation of the
Juan F. Delgado +9 more
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