Results 11 to 20 of about 4,776,365 (127)

Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses. [PDF]

PLoS Pathogens, 2016
Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response.
Susanne L Linderman, Scott E Hensley
doaj   +2 more sources

Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity. [PDF]

J Clin Invest, 2023
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19).
Aguilar-Bretones M, Fouchier RA, Koopmans MP, van Nierop GP.   +3 more
europepmc   +3 more sources

A speed limit on serial strain replacement from original antigenic sin. [PDF]

Proc Natl Acad Sci U S A
Many pathogens evolve to escape immunity, yet it remains difficult to predict whether immune pressure will lead to diversification, serial replacement of one variant by another, or more complex patterns.
McGough L, Cobey S.
europepmc   +2 more sources

The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination [PDF]

Clinical Immunology Communications, 2021
Ger Rijkers, Frans van Overveld
exaly   +2 more sources

Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains

mBio, 2021
Prime-boost vaccinations of humans with different H5 strains have generated broadly protective antibody levels. However, the effect of an individual’s H5 exposure history on antibody responses to subsequent H5 vaccination is poorly understood.
Jiong Wang, Dongmei Li, Sheldon Perry, Shannon P. Hilchey, Alexander Wiltse, John J. Treanor, Mark Y. Sangster, Martin S. Zand   +7 more
doaj   +1 more source

HLA, Immune Response, and Susceptibility to COVID-19

Frontiers in Immunology, 2021
The severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2) that appeared in December 2019 has precipitated the global pandemic Coronavirus Disease 2019 (COVID-19).
Fataneh Tavasolian, Mohsen Rashidi, Gholam Reza Hatam, Marjan Jeddi, Ahmad Zavaran Hosseini, Sayed Hussain Mosawi, Sayed Hussain Mosawi, Elham Abdollahi, Robert D. Inman, Robert D. Inman   +9 more
doaj   +1 more source

Characterization of immune responses induced by immunization with the HA DNA vaccines of two antigenically distinctive H5N1 HPAIV isolates. [PDF]

PLoS ONE, 2012
The evolution of the H5N1 highly pathogenic avian influenza virus (HPAIV) has resulted in high sequence variations and diverse antigenic properties in circulating viral isolates.
Yulong Gao, Zhiyuan Wen, Ke Dong, Gongxun Zhong, Xiaomei Wang, Zhigao Bu, Hualan Chen, Ling Ye, Chinglai Yang   +8 more
doaj   +1 more source

Cluster di Calcolo di OAS-Bologna e Software Scientifico disponibile [PDF]

, 2023
All’interno dell’ Osservatorio di Astrofisica e Scienza dello Spazio di Bologna (OAS), da sempre abbiamo avuto la necessità di strumenti di calcolo potenti e condivisi su cui gli scienziati possano svolgere le elaborazioni sui dati scientifici di ...
GRANDI, PAOLA, PASTORE, Valerio, FINELLI, FABIO, DE CESARE, GIOVANNI, PAOLETTI, DANIELA, GIANOTTI, Fulvio, TORRESI, ELEONORA, BULGARELLI, ANDREA, DE ROSA, Adriano Giuseppe, TACCHINI, ALESSANDRO, FIORETTI, Valentina, FRANCESCHI, ENRICO, CONFORTI, Vito, DADINA, MAURO   +13 more
core   +1 more source

Understanding original antigenic sin in influenza with a dynamical system. [PDF]

, 2011
Original antigenic sin is the phenomenon in which prior exposure to an antigen leads to a subsequent suboptimal immune response to a related antigen. Immune memory normally allows for an improved and rapid response to antigens previously seen and is the ...
Keyao Pan
core   +1 more source

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Viruses, 2019
Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes.
Maria Malm, Timo Vesikari, Vesna Blazevic   +2 more
doaj   +1 more source