Results 91 to 100 of about 5,486,911 (302)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Error modeling of 3-RSR parallel robot based on D-H transformation matrix

Journal of Measurement Science and Instrumentation, 2014
By selecting any one limb of 3-RSR parallel robot as a research object,the paper establishes a position and orientation relationship matrix between the moving platform and the base by means of Denavit-Hartenberg（ D-H） transformation matrix.
LI Rui-qin, YANG Bin
doaj  

IVOA Recommendation: Simple Cone Search Version 1.03

, 2011
This specification defines a simple query protocol for retrieving records from a catalog of astronomical sources. The query describes sky position and an angular distance, defining a cone on the sky.
Hanisch, Robert, Plante, Raymond, Szalay, Alex, Williams, Roy   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Identifying entanglement using quantum "ghost" interference and imaging

, 2004
We report a quantum interference and imaging experiment which quantitatively demonstrates that Einstein-Podolsky-Rosen (EPR) type entangled two-photon states exhibit both momentum-momentum and position-position correlations, stronger than any classical ...
A. Migdall, D. Bedford, D. N. Klyshko, E. Schrödinger, Milena D’Angelo, Sergei P. Kulik, Yanhua Shih, Yoon-Ho Kim   +7 more
core   +1 more source

‘Original Position’ und Reflektives Gleichgewicht

, 1986
1. In seiner Theorie der Gerechtigkeit stellt John Rawls eine hypothetische Entscheidungssituation an den Anfang seiner Uberlegungen. Mit dieser original position, der zentralen Konstruktion der gesamten Theorie, sind zwei grundlegende Probleme verbunden, die nach dem Erscheinen der theory of justice in zahllosen Beitragen immer wieder diskutiert ...
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Rawls and deliberative democracy [PDF]

, 2002
This chapter offers arguments to support the following conjectures: (1) despite claims by Rawls and some commentators, Rawls is not and cannot be a deliberative democrat; the evidence for this can be gleaned by focussing on various interpretations of the
Saward, Michael
core