Results 71 to 80 of about 2,153,835 (285)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The determinants of "domestic" original sin in emerging market economies [PDF]
This paper explains why domestic debt composition in some emerging economies is risky. To this end, it carries out a systematic analysis of the determinants of the so-called domestic original sin, which refers to the inability of emerging economies to ...
Arnaud Mehl, Julien Reynaud
core +3 more sources
What is invariant? On the possibility and perspectives of the evolutionary theology
Studia Koszalińsko-Kołobrzeskie, 2018 The evolutionary theology is a new branch of theology in which the dynamic picture of the origin and development of life in Universe by means of the adaptive processes governed by the natural selection is considered to be the adequate ontological ...
Wojciech Grygiel
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The Original Sin of Writing and Reading
ReligionsThis study examines the possible points of connection between crime and reading on the basis of genre-typical roles and motifs in detective fiction. I aim to identify characteristic reading methods, strategies, locations, events, and professions with ...
Kristián Benyovszky
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
On the origin of death: Paul and Augustine meet Charles Darwin
HTS Teologiese Studies/Theological Studies, 2013 Ever since the 4th century, Christian theologians have linked Romans 5:12–21 with Genesis 2–3. Augustine (354–430), one of the Latin fathers of the Church, propagated the idea of ‘original sin’ according to his reading of these chapters.
Izak J.J. Spangenberg
doaj
Chomsky with Lewis: Human Nature, Science and Language Origin
Scientia et Fides, 2019 This article, in its first part, summarizes Noam Chomsky’s ideas about human nature and their ethico-political consequences, language and its origin and the scope and limitations of experimental science.
Marciano Escutia
doaj +1 more source