Results 51 to 60 of about 361,038 (286)
Les algues vertes (phylum Viridiplantae), sont-elles vieilles de deux milliards d'années ?
Carnets de Géologie, 2006 Bernard TEYSSÈDRE est professeur émérite, ancien directeur d'une unité CNRS/Université de Paris en Sciences Humaines et Sociales. Il a dirigé une école doctorale en Arts et Sciences de l'Art et l'Institut d'Esthétique des Arts contemporains.
Teyssèdre Bernard
doaj
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Sur le passé romain des anciens Bretons. [PDF]
, 1996 La recherche contemporaine inscrit les origines bretonnes dans le cadre des "déplacements de peuples" survenu vers la fin de l'Antiquité et au début du moyen Age dans l'Empire Romain.
Cassard, Jean-Christophe
core +2 more sources
Quête des origines et cinéma : À propos de Nobody’s Business d’Alan Berliner [PDF]
, 2004 Reconnu comme l’une des figures marquantes du cinéma indépendant américain actuel, Alan Berliner est un émigré de troisième génération : son grand-père a quitté Rigrod (Pologne) pour les États-Unis au début du siècle.
Odin, Roger
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
MARC BERNARD : LE VOYAGE AUX ORIGINES [PDF]
Studii si Cercetari Filologice: Seria Limbi Romanice, 2018 Dans cet article, nous révisons l’œuvre de Marc Bernard, prix Goncourt 1942 par Pareils à des enfants et classé souvent parmi les auteurs de la littérature prolétarienne en France. Notre analyse veut se diriger sur deux récits où il aborde la thématique
Ángeles SANCHEZ HERNANDEZ
doaj
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Les origines et l’évolution du concept d’acteur [PDF]
, 1984 The actor concept, implicit in former social thought, has become explicit in contemporary studies on international life. It is even more pronounced in the realistic and systemic analysis.
Dussault, Paul N.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source