Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
International Journal of Molecular Sciences, 2021 One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as “developmental origins of health and disease” (DOHaD), can have its origins in early life. Offspring MetS can
Chien-Ning Hsu +2 more
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A Chemist's Perspective on the Role of Phosphorus at the Origins of Life. [PDF]
Life (Basel), 2017 The central role that phosphates play in biological systems, suggests they also played an important role in the emergence of life on Earth. In recent years, numerous important advances have been made towards understanding the influence that phosphates ...
Fernández-García C +2 more
europepmc +2 more sources
Synthesis and Characterization of Amino Acid Decyl Esters as Early Membranes for the Origins of Life [PDF]
Membranes, 2022 Understanding how membrane forming amphiphiles are synthesized and aggregate in prebiotic settings is required for understanding the origins of life on Earth 4 billion years ago.
Isabella Lago +3 more
doaj +2 more sources
The algorithmic origins of life [PDF]
Journal of The Royal Society Interface, 2012 Although it has been notoriously difficult to pin down precisely what is it that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property.
S. Walker, P. Davies
semanticscholar +5 more sources
Quantifying the origins of life on a planetary scale. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance In this paper, we describe an equation to estimate the frequency of planetary “origin of life”-type events that is similar in intent to the Drake Equation but with some key advantages—specifically, our formulation makes an explicit ...
Scharf C, Cronin L.
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A Strategy for Origins of Life Research. [PDF]
Astrobiology, 2015 Contents 1. Introduction 1.1. A workshop and this document 1.2. Framing origins of life science 1.2.1. What do we mean by the origins of life (OoL)? 1.2.2. Defining life 1.2.3. How should we characterize approaches to OoL science? 1.2.4. One path to life
Scharf C +36 more
europepmc +2 more sources
Bulk measurements of messy chemistries are needed for a theory of the origins of life. [PDF]
Philos Trans A Math Phys Eng Sci, 2017 Guttenberg N +5 more
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Constraint Closure Drove Major Transitions in the Origins of Life [PDF]
Entropy, 2021 Niles Lehman
exaly +2 more sources
On the origins of life’s homochirality: Inducing enantiomeric excess with spin-polarized electrons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Essential biomolecules, like amino acids and sugars, are chiral; they exist in mirror symmetrical pairs named enantiomers. However, modern life selectively uses only one of the enantiomers. The origin of this chiral symmetry breaking remains
S. Ozturk, D. Sasselov
semanticscholar +1 more source
Novel Apparatuses for Incorporating Natural Selection Processes into Origins-of-Life Experiments to Produce Adaptively Evolving Chemical Ecosystems. [PDF]
Life (Basel), 2022 Origins-of-life chemical experiments usually aim to produce specific chemical end-products such as amino acids, nucleic acids or sugars. The resulting chemical systems do not evolve or adapt because they lack natural selection processes. We have modified
Root-Bernstein R, Brown AW.
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