Results 41 to 50 of about 1,434,799 (290)

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

BMC Cancer, 2018
Background Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore ...
Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang, Jeff Holst   +9 more
doaj   +1 more source

The building blocks and origins of life

HTS Teologiese Studies/Theological Studies, 2020
The building blocks and origins of life have fascinated scientists since the earliest of times. What is required for life to work in terms of building blocks?
Dirk U. Bellstedt
doaj   +1 more source

Magnetism, FeS colloids, and Origins of Life

, 2010
A number of features of living systems: reversible interactions and weak bonds underlying motor-dynamics; gel-sol transitions; cellular connected fractal organization; asymmetry in interactions and organization; quantum coherent phenomena; to name some ...
A Ahniyaz, A Engel, A Etxeberria, A Nagya, A Preisinger, A Pross, A Yethiraj, AD Patel, AD Patel, AD Patel, AG Cairns-Smith, AJ Boyce, AJ Boyce, AL Buchachenko, AM Selvam, AM Tishin, AP Roberts, AS Keys, AY Zubarev, AY Zubarev, B-O Küppers, BA Grzybowski, C Bustamante, C Huber, C Jaryznski, C Tenailleau, C Viedma, CR Vestal, D Abel, D Abel, D Rickard, D Rickard, D Rickard, den Hollander WThF, DG Drubin, DI Khomskii, DJ Vaughan, DJ Vaughan, DL Stein, DS Kelley, E Schroedinger, EJ Milner-White, EJ Milner-White, ET Degens, EV Koonin, F Heylighen, FJ Dyson, FM Harold, G Mitra-Delmotte, G Nicolis, G Wächtershäuser, GL Früh-Green, GN Ling, GO Arrhenius, GS Engel, H Frohlich, H Frohlich, H Ohfuji, H Ohfuji, H Ohldag, HH Pattee, HH Pattee, HM Palmer, I Adler, I Kant, IK Kominis, J Al-Khalili, J Breivik, J Charnock, J Cheon, J Dyment, J Hemberger, J Higo, J Hoffmeyer, J Li, J McFadden, J Spitzer, J Torbet, JC Weaver, JD Bernal, JK Jain, JL Kirschvink, JL Kirschvink, JL Kirschvink, JM McBride, JP Ferris, JS Ban, JS Beard, JT Trevors, K Hatori, K Matsuno, K Righter, KA Michie, KM Doll, LE Orgel, LE Orgel, LE Orgel, LS Levitov, M Haw, M Jibu, M Mostovoy, M Polyani, M Winkelhofer, M Wolthers, M Wu, MF Chaplin, MF Chaplin, Mitra-Delmotte, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MJ Russell, MO Goerbig, MP Pileni, NE Mavromatos, NJ Cerf, P Baaske, P Bak, P Galland, P Wasilewski, PCW Davies, PCW Davies, PCW Davies, PW Anderson, R Hazen, R Kopelman, R Lifshitz, R Palm, R Pastor-Satorras, R Phillips, R Shapiro, R Skomski, RA Dunlap, RCL Larter, RD Astumian, RD Astumian, RE Rosensweig, RT Wilkin, RW Chantrell, S Hagan, S Itoh, S Kauffman, S Lloyd, S Odenbach, S Sun, S Taketomi, S Traverso, SA Newman, T Schroeder, V Fritsch, V Hoffmann, VK Mer La, VM Goldschmidt, VN Manoharan, VTh Marteinsson, VV Korolev, W Cruz da, W Martin, W Martin, WH Zurek, Y Kwon, Y Lalatonne, Y Min, Z Merali, Z Sawlowicz, Z Sawlowicz, Z Wang   +172 more
core   +1 more source

Prospective Cohort Study of Emergency Department Visit Frequency and Diagnoses Before and During COVID-19 Pandemic in Urban, Low-Income, US- and Foreign-Born Mothers in Boston, MA

Western Journal of Emergency Medicine, 2023
Background: The coronavirus 2019 (COVID-19) pandemic fundamentally changed how populations interface with the healthcare system. Despite historical spikes in US mortality during the pandemic, emergency department (ED) visits were paradoxically low.
Valerie Osula, Serena Rusk, Lingxin Hao, Bhakti Hansoti, Alison Gemmill, Xiumei Hong, Guoying Wang, Colleen Pearson, William G. Adams, Xiaobin Wang   +9 more
doaj   +1 more source

THE ORIGIN OF CANCER AND THE ORIGIN OF LIFE. [PDF]

The Lancet, 1911
n ...
openaire   +2 more sources

Evidence of Late Miocene Peri-Tibetan Aridification From the Oldest Asian Species of Sandgrouse (Aves: Pteroclidae)

Frontiers in Ecology and Evolution, 2020
The partial skeleton of a new extinct taxon, Linxiavis inaquosus, from the Liushu Formation (6–9 Ma) at the edge of the Tibetan Plateau in Gansu Province, China is the most substantial known fossil record of sandgrouse (Pteroclidae).
Zhiheng Li, Zhiheng Li, Thomas A. Stidham, Thomas A. Stidham, Thomas A. Stidham, Tao Deng, Tao Deng, Zhonghe Zhou, Zhonghe Zhou   +8 more
doaj   +1 more source

Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide

Life, 2023
A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite
Stuart A. Harrison, William L. Webb, Hanadi Rammu, Nick Lane   +3 more
doaj   +1 more source

Systems Analysis for Peptide Systems Chemistry

Life, 2019
Living systems employ both covalent chemistry and physical assembly to achieve complex behaviors. The emerging field of systems chemistry, inspired by these biological systems, attempts to construct and analyze systems that are simpler than biology ...
Martha A. Grover, Ming-Chien Hsieh, David G. Lynn   +2 more
doaj   +1 more source

Provenance does matter: links between winter trophic segregation and the migratory origins of European robins [PDF]

, 2016
Amongst migratory species, it is common to find individuals from different populations or geographical origins sharing staging or wintering areas.
Bearhop, Stuart,, Campos, Ana R.,, Catry, Paulo,, Granadeiro, José Pedro,, Lund University., Neto, Júlio M.,, Newton, Jason,, Ramos, Jaime,   +7 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source