(Re-)Emergence of Oropouche Virus (OROV) Infections: Systematic Review and Meta-Analysis of Observational Studies [PDF]
VirusesOropouche Virus (OROV; genus of Orthobunyavirus) is the causal agent of Oropouche Fever (OF). Due to the lack of specific signs and symptoms and the limited availability of diagnostic tests, the actual epidemiology of OROV infections and OF has been ...
Antonio Cascio +2 more
exaly +5 more sources
Oropouche virus infects primary human intestinal organoids and is inhibited by type I and III interferon treatment [PDF]
mBioOropouche virus (OROV), a neglected arbovirus, has historically been considered a self-limiting infection associated with febrile illness. However, the recent surge in cases since late 2023 has been marked by atypical outcomes, highlighting its ...
Xin Wang +8 more
doaj +3 more sources
Viruses, 2018 Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America.
Papadopoulou C +2 more
exaly +4 more sources
Screening for Oropouche virus in wild bird samples collected from wildlife rehabilitation centers, Florida, United States, 2021–2024 [PDF]
Frontiers in Public HealthOropouche virus (OROV) is an emerging orthobunyavirus whose range has recently expanded in the Americas, with recent outbreaks in Cuba and travel-associated cases reported in the United States, raising concerns about the potential for its establishment ...
Brent C. Newman, Rebecca H. Hardman
doaj +2 more sources
Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model [PDF]
Nature CommunicationsOropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy.
Krista B. Gunter +13 more
doaj +2 more sources
A VLP-based mRNA vaccine elicits potent humoral and cellular immunity against Oropouche virus [PDF]
mBioOropouche virus (OROV) is reemerging in the Americas, along with a growing threat to global public health. Recent outbreaks have witnessed the first reported fatalities, vertical transmissions, and intercontinental importations of OROV, underscoring its ...
Yuren Shi +9 more
doaj +2 more sources
Oropouche virus causes acute hepatitis in mice controlled by type I interferons [PDF]
Journal of VirologyOropouche virus (OROV), a member of the Peribunyaviridae family endemic to South America, is a current public health threat. The recent OROV outbreak driven by a novel reassortant strain has caused a dramatic increase in cases in 2024 (13,785 in Brazil ...
Cade E. Sterling +8 more
doaj +2 more sources
Seroepidemiologic Study of Oropouche Virus, Amazonas State, Brazil, 2015–2016 [PDF]
Emerging Infectious DiseasesWe conducted a cross-sectional serosurvey for Oropouche virus (OROV) among residents of Amazonas State, Brazil, during 2015–2016. We detected OROV neutralizing antibodies in 85/814 (10.4%) participants; seroprevalence was higher in Manaus (49/440 [11.1%]
Julia Forato +8 more
doaj +2 more sources
Lineage-matched Oropouche virus mRNA-LNP vaccines confer complete, cross-protective immunity in mice [PDF]
mBioOropouche virus (OROV) is an emerging orthobunyavirus responsible for recurrent and increasingly widespread outbreaks across South and Central America, including a recent epidemic that elevated global concern.
Yumiko Yamada +11 more
doaj +2 more sources
Oropouche virus outbreaks in northeast Brazil between 2024-25 are characterized by sustained transmission and spread to newly affected areas. [PDF]
PLoS Neglected Tropical DiseasesOropouche virus (OROV) has recently expanded in Brazil, establishing transmission in non-endemic regions. This study aims to integrate epidemiological and molecular data to investigate OROV spread in Northeast (NE) Brazil between 2024 and 2025.
Elverson Soares de Melo +21 more
doaj +2 more sources