Oropouche Virus (OROV) Vaccine Development for Vulnerable Populations: Epidemiological Context, Challenges and Future Directions [PDF]
VaccinesOropouche virus (OROV) is an emerging arthropod-borne virus in the Americas that has evolved from a pathogen historically restricted to forest environments into an increasingly important regional and international public health concern. Despite decades of documented circulation, the true burden of OROV infection remains substantially underestimated ...
Wenrui Wu
exaly +4 more sources
VirusesOropouche Virus (OROV; genus of Orthobunyavirus) is the causal agent of Oropouche Fever (OF). Due to the lack of specific signs and symptoms and the limited availability of diagnostic tests, the actual epidemiology of OROV infections and OF has been ...
Antonio Cascio +2 more
exaly +6 more sources
VirusesOropouche virus (OROV) is an emerging arbovirus endemic in Latin America and the Caribbean that causes Oropouche fever, a febrile illness that clinically resembles some other arboviral infections.
David Baud +2 more
exaly +6 more sources
Serological and viral prevalence of Oropouche virus (OROV): A systematic review and meta-analysis from 2000–2024 including human, animal, and vector surveillance studies [PDF]
PLoS Neglected Tropical DiseasesBackground Oropouche virus (OROV) is an emerging arbovirus primarily transmitted by biting midges and is increasingly recognized as a public health threat in Central and South America. With over 11,000 confirmed cases reported in 2024, a ten-fold increase from the previous year, its transmission dynamics and ...
Máiréad G Whelan, Harriet Ware
exaly +4 more sources
VirusesThe discovery that the Oropouche virus (OROV) can be transmitted vertically from an infected pregnant mother to the fetus, resulting in fetal and placental OROV infection, miscarriage, stillbirth, and congenital malformations including microcephaly, has ...
Mija Ververs +2 more
exaly +5 more sources
Screening for Oropouche virus in wild bird samples collected from wildlife rehabilitation centers, Florida, United States, 2021-2024. [PDF]
Front Public HealthOropouche virus (OROV) is an emerging orthobunyavirus whose range has recently expanded in the Americas, with recent outbreaks in Cuba and travel-associated cases reported in the United States, raising concerns about the potential for its establishment ...
Newman BC, Hardman RH.
europepmc +2 more sources
Oropouche virus infects primary human intestinal organoids and is inhibited by type I and III interferon treatment. [PDF]
mBioOropouche virus (OROV), a neglected arbovirus, has historically been considered a self-limiting infection associated with febrile illness. However, the recent surge in cases since late 2023 has been marked by atypical outcomes, highlighting its ...
Wang X +8 more
europepmc +2 more sources
A VLP-based mRNA vaccine elicits potent humoral and cellular immunity against Oropouche virus. [PDF]
mBioOropouche virus (OROV) is reemerging in the Americas, along with a growing threat to global public health. Recent outbreaks have witnessed the first reported fatalities, vertical transmissions, and intercontinental importations of OROV, underscoring its ...
Shi Y +9 more
europepmc +2 more sources
Lineage-matched Oropouche virus mRNA-LNP vaccines confer complete, cross-protective immunity in mice. [PDF]
mBioOropouche virus (OROV) is an emerging orthobunyavirus responsible for recurrent and increasingly widespread outbreaks across South and Central America, including a recent epidemic that elevated global concern.
Yamada Y +11 more
europepmc +2 more sources
What are the vector species of the Oropouche virus? [PDF]
Pest Manag SciHere, we review the timeline of Oropouche virus (OROV) detection in various hematophagous Diptera, from 1955 to date, including mosquitoes and midges. All vector competence experiments also are described. The results suggest that Culicoides are the primary vectors.
Ayres CFJ +3 more
europepmc +2 more sources