Results 231 to 240 of about 5,265,871 (311)

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

From hope to health: improving sexual and reproductive health knowledge among adolescent orphan girls through the 'HopeBox' intervention in Bangladesh. [PDF]

J Glob Health
Rahman F, Rokaiya R, Naznin S, Patwary MH, Rahman SM, Hossain L, Arafath Y, Munir Z, Sayeed A, Momtaz S, Ether ST, Siddique AB, Munir N, Hossain MM, Hoque MS, Mohsin M, Nahar Q, El Arifeen S, Rahman AE, Ahmed A.   +19 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Anaesthetic considerations in an orphan disease with skeletal anomalies.

Indian J Anaesth, 2016
Datta R, Agarwal J, Sharma DK.
europepmc   +1 more source

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

The Africa We Want: A Perspective on the African Code Against Cancer To Be Developed for Sub‐Saharan Africa

International Journal of Cancer, Volume 159, Issue 12, Page 2861-2869, 15 December 2026.
ABSTRACT Sub‐Saharan Africa (SSA) faces a unique cancer burden, characterized by a disproportionately high mortality‐to‐incidence ratio, a large share of infection‐related cancers, and distinct environmental exposures. Implementation of national policies on primary prevention is limited, and public literacy regarding cancer risk and curability remains ...
Anthony Kityo, Phyllis Ohene‐Agyei, Felix M. Onyije, Hannah Simba, Annet Nakaganda, Denis Chopera, Kofi Mensah Nyarko, Benido Impouma, Mary Nyangasi, Blandina Mmbaga, Valerie McCormack, Cesaltina Lorenzoni, Miriam Mutebi, Joachim Schüz, Carolina Espina   +14 more
wiley   +1 more source

Reconceiving orphan drug market exclusivity as a conditional public-law entitlement: a sustainable regulatory governance model with comparative lessons for China. [PDF]

Front Med (Lausanne)
Quan G, Zhou Y, Liu Y, Wu Y, Yan Y.
europepmc   +1 more source

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller, Romy Busch, Giuseppe Faudone, Felia C. Haffelder, Jan Vietor, Arthur Kardanov, Úrsula López‐García, Arne Hackspacher, Georg Höfner, Vasily Morozov, Susanne F. Koch, Julian A. Marschner, Daniel Merk   +12 more
wiley   +1 more source