Results 241 to 250 of about 5,265,871 (311)

Which drugs will Medicare negotiate next? Predicting selected drugs for Initial Price Applicability Year 2029. [PDF]

J Manag Care Spec Pharm
Li KH, Cousin EM, Sullivan SD.
europepmc   +1 more source

Sex‐Modulated TACSTD2 Methylation and Hormone‐Receptor Axis Interactions in Glioblastoma: Insights Toward Mechanistic Understanding

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley   +1 more source

Clinical benefit, price and epidemiology of orphan drugs approved in China: a cross-sectional analysis of orphan drug policy (ODP) in China. [PDF]

BMJ Open
Yuan J, Li M, Jiang B, Lu ZK, Zhao J, Jiang X.   +5 more
europepmc   +1 more source

Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis

Glia, Volume 74, Issue 12, December 2026.
Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Mathilde Hoareau, Nicolas Diotel, Sepand Rastegar   +2 more
wiley   +1 more source

Clonazepam repurposing in ARID1B patients through conventional RCT and N-of-1 Trials - An experimental strategy for orphan disease development

Sluijs PJvd, Pour KS, Berends C, Kruizinga MD, Müller AR, Eeghen AMv, Girondo MDR, Juachon MJ, Steenbeek D, Cohen AF, Zuiker RG, Santen G.   +11 more
europepmc   +1 more source

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Valuation of Medical Innovation in Orphan Diseases with a Focus on Small Investors and Limited Diversifiable Risks. [PDF]

J Mark Access Health Policy
Nuijten M, Gelder PV.
europepmc   +1 more source

The Circulating Cholangiocarcinoma Protein Biomarkers CRP and MASP2 Also Predict Gallbladder Cancer Risk

International Journal of Cancer, Volume 159, Issue 10, Page 2403-2407, 15 November 2026.
ABSTRACT In a recent publication, Lapitz et al. reported differences in serum levels that predict the development of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis prior to clinical manifestation. We examined whether these biomarkers also predict the risk of gallbladder cancer (GBC) in European prospective plasma samples from ...
Linda Zollner, Jeroen Krijgsveld, Dominique Scherer, Justo Lorenzo Bermejo, on behalf of the EULAT Eradicate GBC Consortium   +4 more
wiley   +1 more source