Results 101 to 110 of about 43,399 (123)

Plant‐derived vesicle‐like nanoparticles in food crops: emerging insights into nutritional biofortification and biomedical applications

Plant Biotechnology Journal, EarlyView.
Summary Food crops, as the cornerstone of human nutrition, not only provide essential macronutrients but also encompass a rich spectrum of bioactive compounds that promote health. Of particular significance are underutilized minor crops, which contain unique beneficial components with proven nutraceutical properties. These valuable bioactive components
Jie Wang, Zhaosheng Kong
wiley   +1 more source

The photochemical inheritance of Eduardo Lissi and Juan Grotewold and the intersystem crossings with other inheritances

Photochemistry and Photobiology, EarlyView.
Eduardo Lissi, Dorita Adamo‐Lissi and Juan Grotewold in Aberystwyth, Wales, winter 1961. Upon their return to Buenos Aires in 1963, with their PhD degrees, Lissi and Grotewold started a Chemical Kinetics and Photochemistry group in the School of Sciences (University of Buenos Aires).
Silvia E. Braslavsky, Carlos M. Previtali   +1 more
wiley   +1 more source

Integrated Disease Management, Adaptation and Genomics of Fungal Plant Pathogens in Cropping Systems

Plant Pathology, EarlyView.
Knowledge of the fungal genome and multifaceted evolutionary forces need to be considered together in understanding and managing agricultural plant pathogen adaptation relative to integrated disease management (IDM) strategies. ABSTRACT Crop production systems contribute significantly to maintaining global food security. These systems often involve the
Hayley Wilson, Ido Bar, Kristy Hobson, Niloofar Vaghefi, Toni Petronitis, Rebecca Ford   +5 more
wiley   +1 more source

Two Point‐of‐Care Cardiac Troponin I Immunoassays Have Acceptable Analytical Performance for the Detection of Measurands of Cardiac Troponin I Cardiac Muscle Homogenates From Southern‐Central Black Rhinoceros (Diceros bicornis minor) and Southern White Rhinoceros (Ceratotherium simum simum)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Skeletal and possible cardiac muscle damage has been reported in chemically immobilized and transported African rhinoceros during conservation‐related activities. The extent of cardiac muscle injury in these rhinoceros is unknown due to a lack of validated cardiac troponin I (cTnI) assays.
Yolandi Rautenbach, Leith C. R. Meyer, Amelia Goddard, Peter E. Buss, Emma H. Hooijberg   +4 more
wiley   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Rilzabrutinib for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, Volume 115, Issue 1, Page 4-15, July 2025.
ABSTRACT Advancements in the understanding of ITP pathogenesis have led to significant improvements in disease management through the use of both traditional immunosuppressive strategies and novel targeted therapies. However, a subset of patients remains refractory to treatment or achieves only transient benefits, underscoring the need for alternative ...
Caterina Labanca, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Veronica Manicardi, Nicola Amodio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1743-1753, June 2025.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

Gut‐derived Lactobacillus from exceptional responders mitigates chemoradiotherapy‐induced intestinal injury through methionine‐driven epigenetic modulation

iMeta, Volume 4, Issue 3, June 2025.
Using metagenomic sequencing and bioinformatics analysis of fecal samples from rectal cancer patients and corresponding mouse models, our study identifies a strong association between Lactobacillus abundance and acute chemoradiotherapy‐induced intestinal injury (ACRIII). Elevated Lactobacillus levels before treatment were consistently linked to reduced
Lu Yu, Zhenhui Chen, Shengqi Yin, Qiqing Guo, Yuchuan Chen, Jiaying Li, Yafang Wang, Xiangqiang Liu, Zi Xu, Yaowei Zhang, Yuqin Zhang, Zhihao Zheng, Keli Chen, Yanqing Ding, Hongying Fan, Zhifeng Liu, Yi Ding   +16 more
wiley   +1 more source