Results 121 to 130 of about 160,917 (252)

Genetic variation among progeny shapes symbiosis in a basidiomycete with poplar

open access: yesNew Phytologist, EarlyView.
Summary Forest trees rely on ectomycorrhizal (ECM) fungi for acquiring scarce resources such as water and nutrients. However, the molecular mechanisms governing ECM traits remain inadequately understood, particularly the role of intraspecific fungal variation in root‐tip colonisation and trophic interactions.
Benjamin Dauphin   +9 more
wiley   +1 more source

Milestones On Orphan Medicinal Products Development: The 100 First Drugs for Rare Diseases Approved Throughout Europe [PDF]

open access: yesClinical Therapeutics, 2015
C. Pontes   +8 more
openaire   +3 more sources

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

open access: yesObesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso   +5 more
wiley   +1 more source

Diazoxide--an orphan drug?

open access: yesArchives of Disease in Childhood, 1992
D. Davidson, A. Nunn
semanticscholar   +1 more source

The photochemical inheritance of Eduardo Lissi and Juan Grotewold and the intersystem crossings with other inheritances

open access: yesPhotochemistry and Photobiology, EarlyView.
Eduardo Lissi, Dorita Adamo‐Lissi and Juan Grotewold in Aberystwyth, Wales, winter 1961. Upon their return to Buenos Aires in 1963, with their PhD degrees, Lissi and Grotewold started a Chemical Kinetics and Photochemistry group in the School of Sciences (University of Buenos Aires).
Silvia E. Braslavsky   +1 more
wiley   +1 more source

The effect of leukoreduction and prolonged storage on coagulation in cold‐stored whole blood: An in vitro study

open access: yesVox Sanguinis, EarlyView.
Abstract Background and Objectives Cold‐stored whole blood (CSWB) for haemodynamically unstable bleeding patients is especially convenient when platelets are otherwise unavailable and simple logistics are favoured, as in prehospital situations. Storage times exceeding the currently common 21 days would be beneficial in situations where normal blood ...
Sanna Susila   +6 more
wiley   +1 more source

Effectiveness of Pyridoxal‐5′‐Phosphate in PNPO Deficiency: A Systematic Review

open access: yesJournal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Pyridox(am)ine 5′‐phosphate oxidase (PNPO) deficiency is an ultrarare inherited neurometabolic disease, characterized by primarily neonatal‐onset B6‐responsive epileptic encephalopathies. Treatment often requires sustainable access to high‐quality pyridoxal‐5′‐phosphate (PLP, i.e., active vitamin B6), although some patients (also) respond to ...
Nina N. Stolwijk   +7 more
wiley   +1 more source

Nervonic acid, a long chain monounsaturated fatty acid, improves mitochondrial function in adrenomyeloneuropathy fibroblasts

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 17, Page 4134-4146, September 2025.
Abstract Background and Purpose Nervonic acid plays a vital role in maintaining normal brain and neuronal function. Nervonic acid has gained increasing attention because of its potential neuroprotective and anti‐inflammatory properties. Nonetheless, the beneficial effects of nervonic acid are yet to be fully investigated. Adrenomyeloneuropathy (AMN), a
Chenxu Li   +2 more
wiley   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

open access: yesAdvanced Science, Volume 12, Issue 29, August 7, 2025.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu   +12 more
wiley   +1 more source

PHP6 QUANTITATIVE ANALYSIS OF THE INFLUENCE OF DISEASE AND PRODUCT CHARACTERISTICS ON ORPHAN DRUG PRICES IN EUROPE

open access: yesValue in Health, 2010
A.L. Vataire   +4 more
openaire   +2 more sources

Home - About - Disclaimer - Privacy