Results 131 to 140 of about 68,732 (285)

Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus

Andrology, EarlyView.
ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang, Arndt Hartmann, Robert Stöhr, Katrin Weigelt, Carol Geppert, Frederik A. Stuebs, Matthias W. Beckmann, Bernd Wullich, Helge Taubert, Marios Marcou, Sven Wach   +10 more
wiley   +1 more source

Cooperative research and development opportunities with the National Cancer Institute [PDF]

The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored ...
Sybert, Kathleen
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High pretreatment peripheral blood T‐cell receptor clonality as a predictor of prolonged response in immune thrombocytopenia to the British Journal of Haematology

British Journal of Haematology, EarlyView.
Left panel: Scheme of the XPAG‐immune thrombocytopenia trial. The dexamethasone (DEX) arm consisted of DEX 40 mg/day for days 1–4 for one to three cycles every 28 days to a maximum of 12 weeks, cycles 2 + 3 were optional. Patients randomised to eltrombopag (ETB) + DEX received eltrombopag in combination with a short course of high‐dose DEX beginning on
Paul Schmidt‐Barbo, Christoph Schultheiss, Annaïse J. Jauch, Donjetë Simnica, Gerda Silling, Mathias Hänel, Jörg Chromik, Thomas Stauch, Karolin Trautmann‐Grill, Roland Repp, Clemens Schulte, Bastian Fleischmann, Manfred Welslau, Martina Stauch, Claudia Quiering, Frank Richter, Tamara Tesanovic, Sabine Jahn, Andreas Holbro, Jakob R. Passweg, Axel Matzdorff, Mathias Rummel, Oliver Meyer, Falk Nimmerjahn, Mascha Binder   +24 more
wiley   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, EarlyView.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Orphanhood Status and Antecedents to Placement Among a Multinational Sample of Adults With Care Experience

Child &Family Social Work, EarlyView.
ABSTRACT Globally, millions of children are adopted or placed in alternative care settings (i.e., residential, foster, or kinship care). The current study explores the factors leading to separation from parents and adoption or placement in alternative care by investigating orphanhood status, perceived antecedents to placement, types of alternative care
Nicole Gilbertson Wilke, Jedd Medefind, Amanda Hiles Howard   +2 more
wiley   +1 more source

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches

Developing World Bioethics, EarlyView.
ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley   +1 more source

How to Imagine Educational AI: The Filling of a Pail or the Lighting of a Fire?

Educational Theory, EarlyView.
Abstract Recent advances in artificial intelligence (e.g., machine learning, generative AI) have led to increased interest in its application in educational settings. AI companies hope to revolutionize teaching and learning by tailoring material to the individual needs of students, automating parts of teachers' jobs, or analyzing educational data to ...
Michał Wieczorek, Alberto Romele
wiley   +1 more source

Orphans and other vulnerable children : what role for social protection ? [PDF]

Recent estimates have provided unprecedented numbers of orphans, and vulnerable children, either brought about because of the HIV/AIDS epidemic, or carriers themselves of HIV infections, a relentless growth which has precipitated a multifaceted care ...
Assefaw Tekeste Ghebrekidan, Baingana, Florence, Browsky, Sarah, Connolly, Mark, Devarajan, Shanta, Doryan, Eduardo, Frederiksen, Birger, Gilborn,Laelia, Grosh, Margaret, Haque, Trina, Hodge, Matthew, Hunter, Susan, Kamwendo, Christene, Levine, Anthony [editor], Lorey, Mark, Lukoda, Matthew, MacLeod, Ian, Macleon, Heather, McDermott, Peter, Mulenga, Doreen, Muwonge, Joe, Ramphele, Mamphele, Serpell, Namposya, Subbarao, Kalanidhi, Walker, Christopher, Wangile, Rhoi, Wessells, Mike   +26 more
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