Results 131 to 140 of about 160,917 (252)

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Visual Research of Global Orphan Drug from a Bibliometric Perspective. [PDF]

Drug Des Devel Ther
Wen X, Jin G, Wu C.
europepmc   +1 more source

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier   +24 more
wiley   +1 more source

Editorial: The changing focus of regulatory frameworks around the globe and the opportunities for harmonization. [PDF]

Front Med (Lausanne)
Magrelli A, O'Connor DJ, Stoyanova-Beninska V.   +2 more
europepmc   +1 more source

Effects of Secukinumab on Enthesiophyte and Erosion Progression in Psoriatic Arthritis: A One‐Year Double‐Blind, Randomized, Placebo‐Controlled Trial Using High‐Resolution Peripheral Quantitative Computed Tomography

Arthritis &Rheumatology, Volume 77, Issue 8, Page 1015-1025, August 2025.
Objective This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by using high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Methods This was a phase 4, double‐blind, randomized, placebo‐controlled trial.
Yingzhao Jin, Isaac T. Cheng, Ho So, Billy T. Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk‐Chun Szeto, Jack J. Lee, Ling Qin, Lai‐Shan Tam   +11 more
wiley   +1 more source

Identification of a Highly Virulent <i>Verticillium nonalfalfae</i> Strain Vn011 and Expression Analysis of Its Orphan Genes During Potato Inoculation. [PDF]

Plants (Basel)
Wan M, Chen X, Yi X, Fu Y, Jin Y, Lyu D.
europepmc   +1 more source

Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2

European Journal of Immunology, Volume 55, Issue 8, August 2025.
This study discovered the small molecule 9‐methoxy‐6‐methylindolo[3,2‐b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL‐4, IL‐5, and IL‐13) and promotes the iTreg phenotype by inhibiting Wnt/β‐catenin signaling through NKD2 ...
Jiajun He, Kristy Ou, Michael Schmueck‐Henneresse, Edgar Specker, Jérôme Paul, Marc Nazare, Jens Peter von Kries, Julia K. Polansky, Alf Hamann, Stefan Frischbutter   +9 more
wiley   +1 more source

Advances and Future Challenges in Microbial Food Safety: Volume I. [PDF]

Foods
Lavilla M, Amárita F.
europepmc   +1 more source

Federal 340B Program Payment Scheme for Drugs Designated As Orphan Products: Congressional Clarification Needed to Close the Government-Industry Revolving Door [PDF]

Journal of Clinical Oncology, 2016
Charles L. Bennett, Y. Tony Yang, Brian Chen   +2 more
openaire   +3 more sources

Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity

European Journal of Immunology, Volume 55, Issue 8, August 2025.
In N‐ERD patients, oral aspirin‐induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin‐induced bronchoconstriction. ABSTRACT Previous studies confirmed increased group 2 innate lymphoid
Radosław Kacorzyk, Bogdan Jakiela, Alicja Maciejska, Agnieszka S. Węgrzyn, Adam Ćmiel, Marek Sanak, Lucyna Mastalerz   +6 more
wiley   +1 more source