Results 161 to 170 of about 48,614 (253)

Retraction Note: Distinct Repressive Properties of the Mammalian and Fish Orphan Nuclear Receptors SHP and DAX-1. [PDF]

Mol Cells, 2018
Park YY, Teyssier C, Vanacker JM, Choi HS.   +3 more
europepmc   +1 more source

Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor

Birth Defects Research, Volume 118, Issue 5, May 2026.
ABSTRACT Background Fluoride has come under recent scrutiny regarding concerns over potential neurodevelopmental and endocrine‐related toxicities, with recent reviews by the National Toxicology Program (NTP) and European Food Safety Authority (EFSA) concluding with moderate or reasonable confidence, respectively, that exposure to drinking water having ...
Ashley M. Mudd, Bladimir J. Ovando, George P. Daston   +2 more
wiley   +1 more source

The fascinating history of papillary thyroid carcinoma nuclei: revelation of two nuclear morphologies—“Classical papillary” and “papillary‐like”, with different pathobiologic characteristics

Cancer Cytopathology, Volume 134, Issue 5, May 2026.
Abstract The nucleus of papillary thyroid carcinoma (PTC) has had a fascinating history since its early descriptions by Lindsay in 1960 and his designation of follicular variant papillary thyroid carcinoma (FVPTC) as a subtype of follicular carcinoma (FC). Later, Chen and Rosai revived the awareness of FVPTC and aligned this neoplasm with PTC.
N. Paul Ohori, Jeremy M. Minkowitz, Yuri E. Nikiforov, Raja R. Seethala   +3 more
wiley   +1 more source

Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer. [PDF]

Oncotarget, 2016
Garattini E, Bolis M, Gianni' M, Paroni G, Fratelli M, Terao M.   +5 more
europepmc   +1 more source

Gut Microbiota: A Potential Role in Modulating Carcinogenesis and Response to Anti‐Cancer Therapies

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background The effects of microbiota on cancer are not only limited to their role in oncogenesis, progression and response to anticancer therapies; the disease itself is also influenced by microbiota. In recent investigations, alterations in the gut bacterial community between cancer patients and healthy individuals have been reported ...
Awgichew Shewasinad Yehualashet, Eleni Teklu Fersha, Berhan Begashaw Yikna, Kassahun Dires Ayenew   +3 more
wiley   +1 more source

Nur77 Is Associated With Polyfunctional Properties in Virus‐Specific Human CD8+ T Cells

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Nur77 is associated with a TCF‐1+ memory‐like, polyfunctional profile in virus‐specific human CD8+ T cells across acute‐resolved, vaccinated, and chronic viral infections, and its pharmacologic modulation in vitro enhances the functionality of dysfunctional HIV‐ and HBV‐specific CD8+ T cells in chronic co‐infections. ABSTRACT Human CD8+ T cells undergo
Fabiola Martel, Daniel Rincón, Caroline Passaes, Leonardo Arévalo, Marcela Torres, Natalia Ramirez, Carlos F. Narváez, Jessica F. Toro, Otto Sussmann, Manuel A. Franco, José Mateus, John Sidney, Alessandro Sette, Asier Sáez‐Cirión, Federico Perdomo‐Celis   +14 more
wiley   +1 more source

Epidemiology, Risk Factors and Pathophysiology of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: An Update

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin, Paul Henderson, Richard Pollok, Natália Queiroz, Luca Fabris, Edoardo Vincenzo Savarino, Iago Rodríguez‐Lago, Brigida Barberio   +7 more
wiley   +1 more source

ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery. [PDF]

Database (Oxford), 2015
Nanduri R, Bhutani I, Somavarapu AK, Mahajan S, Parkesh R, Gupta P.   +5 more
europepmc   +1 more source

Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Riboflavin (RF, vitamin B2) is an essential vitamin of which the co‐factors are critical to numerous cellular processes. RF is used as a treatment for inherited metabolic diseases (IMDs), although its effectiveness in many disorders has not been established.
Bregje Jaeger, Nina N. Stolwijk, Femke Aaldering, Charlotte A. Ruys, Marije Smits, Nicole I. Wolf, Carla E. M. Hollak, Annet M. Bosch   +7 more
wiley   +1 more source

Orphan Nuclear Receptors in Metabolic Dysfunction-associated Steatotic Liver Disease Development. [PDF]

J Clin Transl Hepatol
Li H, Chen J, Huang Z, Chen M.
europepmc   +1 more source