Results 211 to 220 of about 48,614 (253)
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The orphan nuclear receptors in cancer and diabetes
Journal of Receptor and Signal Transduction Research, 2013The orphan nuclear receptors (ONRs) are a vital class of transcriptional regulators belonging to the larger nuclear receptors (NRs) superfamily in higher eukaryotes. As a result of non-identification of endogenous physiological ligands for this class of NRs, they are designated as "orphans".
Harmit S Ranhotra
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Orphan Nuclear Receptors: From Gene to Function* [PDF]
Endocrine Reviews, 1999 I. Introduction II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of action III. Orphan Nuclear Receptors A. Definition B. Nomenclature C. Structural and functional diversity IV. Novel Hormone Response Systems: RXR and Its Heterodimeric Partners A. RXR: rexinoids B. PPAR: multiple ligands, multiple functions C.
Vincent Giguere
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Orphan Nuclear Receptors in Colorectal Cancer
Pathology and Oncology Research, 2018 Colorectal cancer is one of the most common cancers worldwide, with an overall increased incidence annually. Despite improvements in treatment and surveillance, almost 50% develop recurrent and/or distant disease. Unknown cellular processes are the fundamental cause for treatment failure and metastatic disease. The interplay of chronic inflammation and
Michael E Kelly +2 more
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Orphan Nuclear Receptor Modulators
Current Topics in Medicinal Chemistry, 2003Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression and play a critical role in endocrine signaling. Orphan nuclear receptors belong to this gene super-family but their target genes and physiological function have not been completely elucidated.
Raju, Mohan, Richard A, Heyman
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Orphan nuclear receptors adopted by crystallography
Current Opinion in Structural Biology, 2005Of the large nuclear hormone receptor superfamily of proteins, orphan nuclear receptors have remained a mystery owing to their lack of identified ligands and their constitutive nature. Now, structures of several ligand-binding domains of orphan receptors have provided some surprising insights that were not anticipated from molecular studies. Therefore,
Holly A, Ingraham, Matthew R, Redinbo
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2000
The nuclear receptor superfamily consists of a class of transcription factors comprising more than 100 different proteins. In contrast to membrane-bound receptors, the nuclear receptors are intracellular and act by controlling the activity of genes directly. Most members of this family bind directly to small lipidsoluble signaling molecules, or ligands,
Deepak S. Lala, Richard A. Heyman
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The nuclear receptor superfamily consists of a class of transcription factors comprising more than 100 different proteins. In contrast to membrane-bound receptors, the nuclear receptors are intracellular and act by controlling the activity of genes directly. Most members of this family bind directly to small lipidsoluble signaling molecules, or ligands,
Deepak S. Lala, Richard A. Heyman
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Orphan nuclear receptor function in the ovary
Frontiers in Bioscience, 2007Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction. Within the ovary, GCNF (NR6A1) expression is restricted to the oocyte, while SF-1 (NR5A1) is expressed only in the somatic cells, such as ...
Huajun, Zhao +3 more
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Opportunities and challenges in targeting orphan nuclear receptors
Chemical Communications, 2023Nuclear receptor modulation enables pharmacological control of gene expression and holds great therapeutic potential. Chemical tools are lacking for many nuclear receptors but needed to reveal new therapeutic opportunities.
Laura Isigkeit, Daniel Merk
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The mammalian orphan nuclear receptors: orphans as cellular guardians
Journal of Receptors and Signal Transduction, 2010In classical endocrinology, receptors are molecules that bind a hormone or a ligand to transduce signal within a target cell. Later, however, many intracellular receptors have been discovered in mammals, which have not been shown to bind endogenous ligands and are now are referred as "orphan receptors." The orphan receptors share high degree of ...
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