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Gene Silencing by Nuclear Orphan Receptors
2004Nuclear orphan receptors represent a large and diverse subgroup in the nuclear receptor superfamily. Although putative ligands for these orphan members remain to be identified, some of these receptors possess intrinsic activating, inhibitory, or dual regulatory functions in development, differentiation, homeostasis, and reproduction.
Ying, Zhang, Maria L, Dufau
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Orphan Nuclear Receptors: Shifting Endocrinology into Reverse
Science, 1999Steroid and thyroid hormones and vitamin A metabolites (retinoids) regulate the expression of complex gene programs by binding to members of the nuclear receptor family of ligand-activated transcription factors. The nuclear receptor family also includes many “orphan” members that currently lack known ligands but that represent candidate receptors for ...
Steven A Kliewer +2 more
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Diversity and Function of Orphan Nuclear Receptors in Nematodes
Critical Reviews in Eukaryotic Gene Expression, 2002Nuclear receptors (NRs) have key regulatory functions in a wide range of biological processes and are one of the most abundant classes of transcriptional regulators in metazoans. NRs are particularly numerous in nematodes, in which the NR gene family has undergone extensive expansion and diversification, providing an evolutionary structure function ...
Van Gilst, Marc +2 more
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Chemical Genomics of Orphan Nuclear Receptors
2003The steroid hormone, thyroid hormone, retinoic acid, and vitamin D receptors are members of a family of ligand-activated transcription factors (Mangelsdorf et al. 1995). These nuclear hormone receptors contain two signature domains, a central double zinc finger DNA-binding domain (DBD) and a C-terminal ligand-binding domain (LBD) (Fig. 1).
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Assignment of the orphan nuclear receptor Nurr1 by NMR
Biomolecular NMR Assignments, 2010The orphan nuclear receptor Nurr1 has been implicated in a number of conditions including Parkinson's disease and Schizophrenia. As such, it is of interest to study its interactions with other proteins, possibly mediated by small molecules, considering possible use as a drug target. We produced (2)H, (15)N, (13)C labelled-Nurr1 to generate the backbone
Paul, Michiels +5 more
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Emerging Roles of Orphan Nuclear Receptors in Cancer
Annual Review of Physiology, 2014A growing body of evidence suggests that a subset of orphan nuclear receptors are amplified and prognostic for some human cancers. However, the specific roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood.
Sung Hee, Baek, Keun Il, Kim
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Orphan nuclear receptors in T lymphocyte development
Journal of Leukocyte Biology, 2002AbstractLymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development.
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Orphan Nuclear Receptors and Their Ligands
1998Nuclear hormone receptors constitute a superfamily of related transcription factors that mediate the actions of nuclear-acting hormones including glucocorticoids, mineralocorticoids, estrogens, progestins, androgens, thyroid hormones, vitamin D, and retinoic acid (Mangelsdorf and Evans 1995).
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