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Orthobiologics Revisited: A Concise Perspective on Regenerative Orthopedics [PDF]

Current Issues in Molecular Biology
At the forefront of regenerative medicine, orthobiologics represent a spectrum of biological substances that offer promising alternatives for tissue repair and regeneration.
Gabriel Santos, José F S D Lana, André Kruel   +2 more
exaly   +5 more sources

Orthobiologics and hyaluronic acid usage in the Netherlands: an electronic survey of 265 orthopaedic surgeons and sports physicians [PDF]

Journal of Experimental Orthopaedics, 2021
Purpose “Biologic therapies” in the field of orthopaedic surgery and sports medicine, so called orthobiologics, have been gaining significant interest from physicians and patients, with increasing usage over the recent years. The aim of this study is to (
M P J van den Bekerom
exaly   +5 more sources

Artificial Intelligence-Guided Precision Orthobiologics in Musculoskeletal Conditions [PDF]

Journal of Orthopaedic Case Reports
Introduction: The use of orthobiologics such as autologous peripheral blood-derived orthobiologics, bone marrow-derived biologics, adipose tissue-derived biologics, mesenchymal stem cells, and extracellular vesicles is gaining traction in the field of ...
Sanjeevi Bharadwaj, Naveen Jeyaraman, Subasri Balasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu, Madhan Jeyaraman   +5 more
doaj   +3 more sources

What Do Patients Know About Orthobiologics? Perceived Efficacy, Safety, and Factors Influencing Treatment Decisions [PDF]

Orthopaedic Journal of Sports Medicine
Background: The use and research of orthobiologics have significantly grown in recent decades, yet patient understanding and perceptions remain largely unexplored.
Jose Rafael Garcia MD, Lucas V. Pallone MD, Ron Gilat MD, Cameron Gerhold BS, Trevor A. Poulson MS, Benjamin Kerzner MD, Felicitas Allende MD, Amelia Hummel MD, Adam B. Yanke MD, PhD, Brian J. Cole MD, MBA, Nikhil N. Verma MD, Jorge Chahla MD, PhD   +11 more
doaj   +3 more sources

Application of Orthobiologics in Achilles Tendinopathy: A Review

Life, 2022
Orthobiologics are biological materials that are intended for the regeneration of bone, cartilage, and soft tissues. In this review, we discuss the application of orthobiologics in Achilles tendinopathy, more specifically.
Lucas Fonseca, Ramya Lakshmi Rajendran, Gabriel Santos   +2 more
exaly   +4 more sources

Orthobiologics and Peptide Therapy for Central Nervous System Repair in Neurodegenerative Conditions [PDF]

Cells
Alzheimer’s disease and Parkinson’s disease remain the most prevalent neurodegenerative disorders associated with aging and continue to lack curative treatments. Their pathophysiology is often multifaceted, encompassing protein aggregation, mitochondrial
Cézar Augusto Alves de Oliveira, Bernardo Scaldini Oliveira, Amanda Scaldini Oliveira, Rafael Duarte de Souza Loduca, Carlos Roberto Massella Junior, Gabriel Silva Santos   +5 more
doaj   +3 more sources

Recent Evidence for Orthobiologics Combined with Hydrogels for Joint Tissue Regeneration: Focus on Osteoarthritis [PDF]

Gels
Osteoarthritis is a significant global problem, causing pain and limitations, and contributing to socioeconomic expenses. The etiopathogenesis of this disease encloses genetic, biological, and mechanical aspects.
Carola Cavallo, Giovanna Desando, Martina D’Alessandro, Brunella Grigolo, Livia Roseti   +4 more
doaj   +3 more sources

Disparities in Evidence and Media Portrayal of Injectable Orthobiologics for Knee Osteoarthritis: A Systematic Review of Randomized Trials and News Media [PDF]

Orthopaedic Journal of Sports Medicine
Background: Injectable orthobiologics such as platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), and autologous protein solution (APS) have gained popularity as regenerative options for knee osteoarthritis (OA).
Edmund Jia Xi Zhang MBBS, Ryan Wei Loong Tay MBBS, James Hoi Po Hui MBBS (S‘pore), FRCS (Edin), FAMS (S‘pore), Barry Wei Loong Tan MBBS, MRCS (Edin), MMed (Orth), FRCSEd (Orth), FAMS (Ortho Surg)   +3 more
doaj   +2 more sources

Orthobiologics in orthopedic applications: a report from the TMI Havemeyer meeting on orthobiologics

Journal of Cartilage & Joint Preservation, 2022
Readily available and effective therapeutic approaches are increasingly required to overcome the growing demand for optimized management of musculoskeletal degenerative conditions.
Christopher Little, Chilan Leite
exaly   +3 more sources

Considerations in modern regenerative medicine for osteoarthritis [PDF]

EFORT Open Reviews
Current non-surgical managements of osteoarthritis (OA) do not change the clinical course or arrest the progression of the disease, while joint replacement is indicated for end-stage disease. Given these limitations, there is an unmet clinical demand for
Gun-il Im
doaj   +2 more sources