Results 31 to 40 of about 1,617 (180)

Regulatory Considerations of Orthobiologic Procedures

Physical Medicine and Rehabilitation Clinics of North America, 2023
The injection of biologic products for musculoskeletal pathologies is an emerging and promising field; however, dubious and unsafe uses for these products are often marketed. The Food and Drug Administration (FDA) has determined the need for varying degrees of regulation for these products for safety and efficacy.
Jang, Kudo, Berrigan, William A, Mautner, Ken   +2 more
openaire   +4 more sources

Neurobehavioral symptom changes following bilateral two-level stellate ganglion blocks in patients with traumatic brain injury: a retrospective analysis of 102 patients

Frontiers in Neuroscience
IntroductionPersistent neurobehavioral symptoms following traumatic brain injury (TBI) can substantially affect patient functioning, and effective treatment options remain limited.
Sean W. Mulvaney, Sanjay Mahadevan, Kyle J. Dineen, Roosevelt J. Desronvilles, Jessi Truett   +4 more
doaj   +1 more source

An Evidence-Based Approach to Orthobiologics for Tendon Disorders.

, 2023
Tendinopathy is a chronic injury that affects both the athletic and general population. Recalcitrant tendinopathy is both frustrating for patients and providers once typical conservative treatments have been exhausted.
Abadin, Andre Armando, Orr, Jordan Pearl, Lloyd, Alexander Raphael, Henning, Phillip Troy, Pourcho, Adam   +4 more
core   +1 more source

Platelet-rich plasma and other injectables in the young athlete

Journal of the Pediatric Orthopaedic Society of North America
: Pediatric sports participation and subsequent injuries have increased in parallel. Additionally, pediatric athletes and families are highly invested in rapid return to pre-injury status and the ability to sustain high impact loads and tension. Recently,
Akbar N. Syed, MD, Kevin Landrum, BS, Theodore J. Ganley, MD   +2 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Are orthobiologics the next chapter in clinical orthopedics? A literature review

, 2018
Orthobiologics are biologically derived materials which aim to promote healing and regeneration of tissues that are the focus of orthopedic surgery. Since bones, ligaments, tendons, and cartilage have different healing and regeneration characteristics ...
Erdem Aras SEZGİN and O. Şahap ATİK, Sezgin, Erdem Aras and Atik, O. Sahap   +1 more
core   +2 more sources

Three-Month Durability of Bilateral Two-Level Stellate Ganglion Blocks for Traumatic Brain Injury: A Retrospective Analysis

Biomedicines
Background/Objectives: The primary aim of the study was to determine if ultrasound-guided, bilateral, two-level stellate ganglion blocks (SGBs), also known as two-level cervical sympathetic chain blocks (2LCSBs), performed on subsequent days, improve ...
Sean W. Mulvaney, Sanjay Mahadevan, Roosevelt J. Desronvilles, Kyle J. Dineen, Kristine L. Rae Olmsted   +4 more
doaj   +1 more source

Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis

Frontiers in Veterinary Science, 2023
Equine veterinarians face challenges in treating horses with osteoarthritic joint pain in routine veterinary practice. All common treatment options aim to reduce the clinical consequences of osteoarthritis (OA) characterized by persistent synovitis and ...
Anna Mayet, Yury Zablotski, Susanne Pauline Roth, Walter Brehm, Antonia Troillet   +4 more
doaj   +1 more source

The Use of Allograft or Xenograft Augmentation in Rotator Cuff Repair Is Cost‐Effective Particularly With Allograft

Arthroscopy, EarlyView.
Purpose To evaluate the cost‐effectiveness of using allograft and xenograft augmentation at the time of primary rotator cuff repair (RCR) using a decision tree analysis. Methods An expected‐value decision tree analysis was developed to compare the costs and outcomes of primary RCR for large tears performed with or without graft augmentation.
Colin Kruse, Marc Daniel Bouchard, Danielle Dagher, Ashraf Hantouly, Antonio Parlange, Mohit Bhandari, Moin Khan   +6 more
wiley   +1 more source

Intra‐articular Orthobiologics Show Statistically but Not Clinically Meaningful Improvements Compared With Viscosupplementation in Knee Osteoarthritis: A Network Meta‐analysis of Randomized Controlled Trials

Arthroscopy, EarlyView.
Purpose To evaluate the comparative effectiveness of intra‐articular platelet‐rich plasma (PRP), stromal vascular fraction (SVF), bone marrow aspirate concentrate (BMAC), umbilical cord‐derived mesenchymal stem cell (UC‐MSC), and hyaluronic acid (HA) for pain relief and functional improvement in patients with knee osteoarthritis through network meta ...
Joo Hyung Han, Min Jung, Kwangho Chung, Hyun‐Soo Moon, Se‐Han Jung, Sung‐Hwan Kim   +5 more
wiley   +1 more source