Results 11 to 20 of about 1,617 (180)

Precision Medicine in Orthobiologics: A Paradigm Shift in Regenerative Therapies [PDF]

Bioengineering
The evolving paradigm of precision medicine is redefining the landscape of orthobiologic therapies by moving beyond traditional diagnosis-driven approaches toward biologically tailored interventions.
Annu Navani, Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Gabriel Azzini, José Fábio Lana   +6 more
doaj   +3 more sources

Evidence-based guidelines on orthobiologics

EFORT Open Reviews
Orthobiologics (OBs) have seen a constant increase in the number of available therapies and their clinical applications. Existing therapies can be categorized into blood-based (e.g., platelet-rich plasma (PRP)) and tissue/cell-based (e.g.
Tobias Winkler, Stephan Oehme, Alexander Hildebrandt, Azzurra Paolucci, Lorenz Pichler   +4 more
doaj   +4 more sources

Orthobiologics in delayed union and non-union of adult long bones fractures: A systematic review [PDF]

Bone Reports
Background: Fracture healing poses a significant challenge in orthopedics. Successful regeneration of bone is provided by mechanical stability and a favorable biological microenvironment. This systematic review aims to explore the clinical application of
Lorenzo Impieri, Andrea Pezzi, Henrique Hadad, Giuseppe M. Peretti, Laura Mangiavini, Nicolò Rossi   +5 more
doaj   +2 more sources

Acellular dermal matrix alone or in combination with subacromial bursa and humeral bone marrow concentrate for augmentation of massive rotator cuff tear repair: a double-blind randomized controlled trial protocol (MODA) [PDF]

Frontiers in Medicine
BackgroundMassive rotator cuff tears are challenging injuries, and there is currently a clinical need to improve treatment outcomes and reduce the re-tear rate.
Marco Cavallo, Luca Solaro, Fabio Tortorella, Valentina Brunello, Davide Melandri, Stefania Pagani, Lucia Martini, Enrico Guerra, Matilde Tschon   +8 more
doaj   +2 more sources

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +2 more sources

Medium-term storage of platelet-derived orthobiologics: a feasible alternative for equine practice [PDF]

Frontiers in Veterinary Science
IntroductionPlatelet-rich plasma (PRP) is commonly used by equine veterinarians. Although PRP is considered a feasible and affordable orthobiologic, its use has been associated with certain drawbacks, such as the time required for protocols and the ...
Sarah Raphaela Torquato Seidel, Joice Fülber, Ângela Perrone Barbosa, Natalia Mori Avellaneda Penatti, Marilene Demasi, Raquel Yvonne Arantes Baccarin   +5 more
doaj   +2 more sources

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York. [PDF]

Arthrosc Sports Med Rehabil
Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on ...
Tauro TM, Hershfeld B, Chen K, Lampert R, Bitterman AD, Cohn RM, Sgaglione NA.   +6 more
europepmc   +2 more sources

Orthobiologics: Current role in Orthopedic Surgery and Traumatology [PDF]

, 2022
Orthobiologics are organic and synthetic materials that help in the cure of musculo-skeletal problems and are utilized in Orthopaedic Surgery, both in and out of the surgical theater, to augment the possibilities of curing bone and soft tissue lesions ...
Rodriguez-Merchan, E. Carlos, Moreno-Garcia, Alonso, Rodriguez-Merchan, E Carlos   +2 more
core   +1 more source

Periodization in Orthobiologics Rehabilitation. [PDF]

J Clin Med
Orthobiologic treatments such as platelet-rich plasma and stem cell therapies are increasingly used to support the healing of tendons, ligaments, and joints. This perspective proposes applying periodization—a structured, progressive model borrowed from athletic training—to rehabilitation following orthobiologic interventions in order to improve ...
Kakavas G, Skarpas G, Totlis T, Kouloumentas P, Malliaropoulos N, Forelli F.   +5 more
europepmc   +4 more sources

Why and how to use the body's own stem cells for regeneration in musculoskeletal disorders: a primer

Journal of Orthopaedic Surgery and Research, 2022
Background Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention.
John P. Furia, Mark A. Lundeen, Jason L. Hurd, David A. Pearce, Christopher Alt, Eckhard U. Alt, Christoph Schmitz, Nicola Maffulli   +7 more
doaj   +1 more source