Results 41 to 50 of about 21,325 (267)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Quasimodules over bounded lattices [PDF]

Mathematica Bohemica
We define a quasimodule $ Q$ over a bounded lattice $\bf L$ in an analogous way as a module over a semiring is defined. The essential difference is that $\bf L$ need not be distributive.
Ivan Chajda, Helmut Länger
doaj   +1 more source

On orthogonal p-adic wavelet bases

Journal of Mathematical Analysis and Applications, 2015
A variety of different orthogonal wavelet bases has been found in L_2(R) for the last three decades. It appeared that similar constructions also exist for functions defined on some other algebraic structures, such as the Cantor and Vilenkin groups and local fields of positive characteristic.
Evdokimov, S., Skopina, M.
openaire   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Existence and Construction of Tangential and Anisotropic Bases in Finite-Dimensional Quadratic Spaces

Mathematics
This paper studies the existence and construction of bases consisting of tangential and anisotropic vectors in finite-dimensional quadratic spaces over fields of characteristic different from two.
Alexander Leones, Pedro Hurtado, John Moreno, Adolfo Pimienta   +3 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Optimal control design for linear - invariant linear singular systems with time using orthogonal functions [PDF]

تصمیم گیری و تحقیق در عملیات, 2019
The problem of solving optimal control of Singular problems in the classic method has a complexity that is solved by approximation of the equations in the problem with orthogonal bases instead of solving the dynamic equation system of a set of static ...
Hamid Tabatabaee, Mahdi Memari
doaj   +1 more source

Trace-orthogonal normal bases

Discrete Applied Mathematics, 1993
For \(q\) a prime power and \(n\geq 2\) an integer, let \(GF(q^ n)\) denote the finite field of order \(q^ n\) considered as a vector space of dimension \(n\) over \(GF(q)\). For \(\alpha\in GF(q^ n)\), a basis of the form \((\alpha, \alpha^ q,\cdots, \alpha^{q^{n-1}})\) is called a normal basis of \(GF(q^ n)\) over \(GF(q)\).
openaire   +3 more sources

Redesigning metabolism based on orthogonality principles [PDF]

Nature Communications, 2017
AbstractModifications made during metabolic engineering for overproduction of chemicals have network-wide effects on cellular function due to ubiquitous metabolic interactions. These interactions, that make metabolic network structures robust and optimized for cell growth, act to constrain the capability of the cell factory.
Aditya Vikram Pandit, Shyam Srinivasan, Radhakrishnan Mahadevan   +2 more
openaire   +3 more sources