Results 51 to 60 of about 22,113 (299)
Geophysical Research Letters, 2022 Various indices have been defined to characterize the phase and amplitude of the Madden‐Julian oscillation (MJO). One widely used index is the outgoing longwave radiation (OLR) based MJO index (OMI), which is calculated using the spatial pattern of 30–96‐
Sarah Weidman +2 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Block Orthonormal Overcomplete Dictionary Learning [PDF]
, 2013 In the field of sparse representations, the overcomplete dictionary learning problem is of crucial importance and has a growing application pool where it is used.
Dumitrescu, Bogdan, Rusu, Cristian
core +1 more source
Redesigning metabolism based on orthogonality principles [PDF]
Nature Communications, 2017 AbstractModifications made during metabolic engineering for overproduction of chemicals have network-wide effects on cellular function due to ubiquitous metabolic interactions. These interactions, that make metabolic network structures robust and optimized for cell growth, act to constrain the capability of the cell factory.
Aditya Vikram Pandit +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Topological Algebras with Orthogonal M-bases [PDF]
, 1985 An M-basis in a topological vector space is a special case of the extended Markushevich basis, and a generalization of the unconditional basis. We study orthogonal bases and orthogonal M-bases in topological algebras, with emphasis on locally convex ...
El-Helaly, Taha Sherif
core
MathematicsThis paper studies the existence and construction of bases consisting of tangential and anisotropic vectors in finite-dimensional quadratic spaces over fields of characteristic different from two.
Alexander Leones +3 more
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Optimal control design for linear - invariant linear singular systems with time using orthogonal functions [PDF]
تصمیم گیری و تحقیق در عملیات, 2019 The problem of solving optimal control of Singular problems in the classic method has a complexity that is solved by approximation of the equations in the problem with orthogonal bases instead of solving the dynamic equation system of a set of static ...
Hamid Tabatabaee, Mahdi Memari
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source