Results 51 to 60 of about 176,435 (287)

Using Volunteer Computing to Study Some Features of Diagonal Latin Squares

Open Engineering, 2017
In this research, the study concerns around several features of diagonal Latin squares (DLSs) of small order. Authors of the study suggest an algorithm for computing minimal and maximal numbers of transversals of DLSs.
Vatutin Eduard, Zaikin Oleg, Kochemazov Stepan, Valyaev Sergey   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Geometric Optimization and Structural Analysis of Cable-Braced Gridshells on Freeform Surfaces

Buildings
In freeform surface grid structures, quadrilateral meshes offer high visual transparency and simple joint connections, but their structural stability is relatively limited.
Xinye Li, Qilin Zhang
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Diverse Subset Selection via Norm-Based Sampling and Orthogonality

IEEE Open Journal of Signal Processing
Large annotated datasets are crucial for the success of deep learning, but labeling data can be prohibitively expensive in domains such as medical imaging.
Noga Bar, Raja Giryes
doaj   +1 more source

OFDM MIMO radar waveform design for targets identification

ETRI Journal, 2018
In order to obtain better target identification performance, an efficient waveform design method with high range resolution and low sidelobe level for orthogonal frequency division multiplexing (OFDM) multiple‐input multiple‐output (MIMO) radar is ...
Ting Bai, Nae Zheng, Song Chen
doaj   +1 more source

Scattering Equations and KLT Orthogonality

, 2013
Several recent developments point to the fact that rational maps from n-punctured spheres to the null cone of D dimensional momentum space provide a natural language for describing the scattering of massless particles in D dimensions.
Cachazo, Freddy, He, Song, Yuan, Ellis Ye   +2 more
core   +1 more source

Orthogonal Fold & Cut

, 2022
We characterize the cut patterns that can be produced by "orthogonal fold & cut": folding an axis-aligned rectangular sheet of paper along horizontal and vertical creases, and then making a single straight cut (at any angle). Along the way, we solve a handful of related problems: orthogonal fold & punch, 1D fold & cut, signed 1D fold & ...
Ani, Joshua, Brunner, Josh, Demaine, Erik D., Demaine, Martin L., Hendrickson, Dylan, Luo, Victor, Madhukara, Rachana   +6 more
openaire   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source