Results 61 to 70 of about 35,860 (292)
Orthogonality spaces associated with posets
, 2022 An orthogonality space is a set equipped with a symmetric, irreflexive relation called orthogonality. Every orthogonality space has an associated complete ortholattice, called the logic of the orthogonality space.
Jenča, Gejza
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On Uniqueness of New Orthogonality via 2-HH Norm in Normed Linear Space
Journal of Function Spaces, 2020 This paper generalizes the special case of the Carlsson orthogonality in terms of the 2-HH norm in real normed linear space. Dragomir and Kikianty (2010) proved in their paper that the Pythagorean orthogonality is unique in any normed linear space, and ...
Bhuwan Prasad Ojha +2 more
doaj +1 more source
Mutually orthogonal unitary and orthogonal matrices
Linear Algebra and its Applications16 pages, no ...
Zhiwei Song, Lin Chen, Saiqi Liu
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Big Data Mining and AnalyticsIt is a vital step to find cocrystal formers of drugs in drug development. Dual-View Learning (DVL) has achieved inspiring progress in predicting cocrystals since compounds can be represented in a dual-source manner (i.e., sequence and 2D structures ...
Haoyang Yu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On acoustic propagation in three-dimensional rectangular ducts with flexible walls and porous linings [PDF]
, 2012 This is the post-print version of the Article. The official published version can be accessed from the links below - Copyright @ 2012 Acoustical Society of AmericaThe focus of this article is toward the development of hybrid analytic-numerical mode ...
Lawrie, JB, Jane B. Lawrie
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source