Results 81 to 90 of about 35,860 (292)

Curvilinearity and Orthogonality

open access: yesCoRR, 2022
We introduce sequences of functions orthogonal on a finite interval: proper orthogonal rational functions, orthogonal exponential functions, orthogonal logarithmic functions, and transmuted orthogonal ...
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Separation and Characterization of Wenjin Tongluo San Essential Oil with a Comprehensive Chromatographic Separation

open access: yesSeparations
The essential oil components of traditional Chinese medicine in-hospital preparation were complex, and one-dimensional chromatographic separation was difficult to completely separate them due to the limited peak capacity.
Chaoyue Wang   +3 more
doaj   +1 more source

Relatively Orthocomplemented Skew Nearlattices in Rickart Rings

open access: yesDemonstratio Mathematica, 2015
A class of (right) Rickart rings, called strong, is isolated. In particular, every Rickart *-ring is strong. It is shown in the paper that every strong Rickart ring R admits a binary operation which turns R into a right normal band having an upper bound ...
Cīırulis Jānis
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Orthogonal Basic Hypergeometric Laurent Polynomials

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2012
The Askey-Wilson polynomials are orthogonal polynomials in$x = cos heta$, which are given as a terminating $_4phi_3$ basic hypergeometric series. The non-symmetric Askey-Wilson polynomials are Laurent polynomials in $z=e^{iheta}$, which are given as a ...
Mourad E.H. Ismail, Dennis Stanton
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Modeling of vibration for functionally graded beams

open access: yesOpen Mathematics, 2016
In this study, a vibration problem of Euler-Bernoulli beam manufactured with Functionally Graded Material (FGM), which is modelled by fourth-order partial differential equations with variable coefficients, is examined by using the Adomian Decomposition ...
Yiğit Gülsemay   +2 more
doaj   +1 more source

ORTHOGONALITY OF STRUCTURED DERIVED ENTITIES [PDF]

open access: yes
Structured entities, derivative entities and their order are presented. The orthogonality metric for structured and derivative entities is build. This metric is implemented.
Ion Ivan   +2 more
core  

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