Results 71 to 80 of about 36,916 (300)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Quantum and electrostatic models of Chebyshev polynomials of type IV

open access: yesDemonstratio Mathematica
In this work, we study the Chebyshev polynomials of the fourth kind as solutions of a singular Sturm–Liouville problem and establish their differential, orthogonality, and extremal properties. We derive a Rodrigues-type formula and a generating function,
Toribio-Milane Juan   +2 more
doaj   +1 more source

Relatively Orthocomplemented Skew Nearlattices in Rickart Rings

open access: yesDemonstratio Mathematica, 2015
A class of (right) Rickart rings, called strong, is isolated. In particular, every Rickart *-ring is strong. It is shown in the paper that every strong Rickart ring R admits a binary operation which turns R into a right normal band having an upper bound ...
Cīırulis Jānis
doaj   +1 more source

On R- Orthogonality in Lorentz-Minkowski plane [PDF]

open access: yes, 2019
Lorentz - Minkowski düzlemi (L2 düzlemi) bir Pseudo-Öklidyen düzlemdir. Bu düzlemdeki iç çarpım Öklid düzlemindeki iç çarpımdan farklı olduğundan iç çapımla ilgili konuları çalışmak oldukça ilginçtir.
Açıkgöz, Abdulaziz, Sönmez, Nilgün
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The principles of orthogonality and confounding in replicated experiments - With Seven Text-figures

open access: yes, 1933
The principle of orthogonality in replicated experiments is discussed and the dangers of non-orthogonality emphasised. The modifications necessary in the ordinary procedure of the analysis of variance when applied to non-orthogonal data are developed ...
Yates, F., Yates, Frank
core   +1 more source

Homogeneity of isosceles orthogonality and related inequalities [PDF]

open access: yes, 2011
We study the homogeneity of isosceles orthogonality, which is one of the most important orthogonality types in normed linear spaces, from two viewpoints.
Wu Senlin   +3 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Modeling of vibration for functionally graded beams

open access: yesOpen Mathematics, 2016
In this study, a vibration problem of Euler-Bernoulli beam manufactured with Functionally Graded Material (FGM), which is modelled by fourth-order partial differential equations with variable coefficients, is examined by using the Adomian Decomposition ...
Yiğit Gülsemay   +2 more
doaj   +1 more source

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