Results 11 to 20 of about 25,011 (183)

A deep learning model for predicting essential proteins based on an attention mechanism [PDF]

open access: yesFrontiers in Genetics
IntroductionEssential proteins are key to cellular viability, yet their experimental identification is costly and time-consuming.MethodsIn this study, DLAM is introduced as a deep learning framework that integrates four complementary biological cues ...
Shunxian Zhou   +4 more
doaj   +2 more sources

Orthology and near-cographs in the context of phylogenetic networks [PDF]

open access: yesAlgorithms for Molecular Biology
Orthologous genes, which arise through speciation, play a key role in comparative genomics and functional inference. In particular, graph-based methods allow for the inference of orthology estimates without prior knowledge of the underlying gene or ...
Anna Lindeberg   +3 more
doaj   +2 more sources

Formation of the system of orthology of the Crimean Tatar literary language [PDF]

open access: yesКрымское историческое обозрение, 2021
The modern Crimean Tatar literary language as a processed supra-dialectal version of the common language has a long history of formation and development.
Adile Emirova
doaj   +1 more source

Ancient duplication, coevolution, and selection at the MHC class IIA and IIB genes of birds

open access: yesFrontiers in Immunology, 2023
IntroductionThe Major Histocompatibility Complex (MHC) of vertebrates is a dynamically evolving multigene family primarily responsible for recognizing non-self peptide antigens and triggering a pathogen-specific adaptive immune response.
Piotr Minias   +3 more
doaj   +1 more source

Humanized yeast to model human biology, disease and evolution

open access: yesDisease Models & Mechanisms, 2022
For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights into human biology. Yeast and humans share several thousand genes despite morphological and cellular differences and over a billion years of separate evolution ...
Aashiq H. Kachroo   +3 more
doaj   +1 more source

‘Posledniy’ [Last] vs ‘Krayniy’ [Latest] in Ontological Presentation

open access: yesНаучный диалог, 2022
The question of replacement in the synonymic pair last — latest is considered. Attention is paid to the characteristics of speech stereotypes and types of frames that form substitution in a synonymic pair.
E. P. Ivanyan, A. M. Klyushina
doaj   +1 more source

Homology-based reconstruction of regulatory networks for bacterial and archaeal genomes

open access: yesFrontiers in Microbiology, 2022
Gene regulation is a key process for all microorganisms, as it allows them to adapt to different environmental stimuli. However, despite the relevance of gene expression control, for only a handful of organisms is there related information about genome ...
Luis Romero   +4 more
doaj   +1 more source

Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents

open access: yesFrontiers in Nutrition, 2023
For decades bitter taste receptors (TAS2R) were thought to be located only in the mouth and to serve as sensors for nutrients and harmful substances. However, in recent years Tas2r have also been reported in extraoral tissues such as the skin, the lungs,
Maria Descamps-Solà   +8 more
doaj   +1 more source

GENESPACE tracks regions of interest and gene copy number variation across multiple genomes

open access: yeseLife, 2022
The development of multiple chromosome-scale reference genome sequences in many taxonomic groups has yielded a high-resolution view of the patterns and processes of molecular evolution.
John T Lovell   +8 more
doaj   +1 more source

Development of a knowledge graph framework to ease and empower translational approaches in plant research: a use-case on grain legumes

open access: yesFrontiers in Artificial Intelligence, 2023
While the continuing decline in genotyping and sequencing costs has largely benefited plant research, some key species for meeting the challenges of agriculture remain mostly understudied.
Baptiste Imbert   +6 more
doaj   +1 more source

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