Results 51 to 60 of about 28,177 (251)
Detecting putative orthologs [PDF]
Bioinformatics, 2003 Abstract Summary: We developed an algorithm that improves upon the common procedure of taking reciprocal best blast hits (rbh) in the identification of orthologs. The method—reciprocal smallest distance algorithm (rsd)—relies on global sequence alignment and maximum likelihood estimation of evolutionary distances to detect orthologs ...
Dennis P. Wall +2 more
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eLife, 2019 Extensive transcriptional alterations are observed in cancer, many of which activate core biological processes established in unicellular organisms or suppress differentiation pathways formed in metazoans.
Anna S Trigos +3 more
doaj +1 more source
The Ortholog Conjecture Revisited: the Value of Orthologs and Paralogs in Function Prediction [PDF]
Bioinformatics, 2019 Abstract The computational prediction of gene function is a key step in making full use of newly sequenced genomes. Function is generally predicted by transferring annotations from homologous genes or proteins for which experimental evidence exists.
Moses Stamboulian +3 more
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SMORE: Synteny Modulator of Repetitive Elements
Life, 2017 Several families of multicopy genes, such as transfer ribonucleic acids (tRNAs) and ribosomal RNAs (rRNAs), are subject to concerted evolution, an effect that keeps sequences of paralogous genes effectively identical.
Sarah J. Berkemer +3 more
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Integration of 1:1 orthology maps and updated datasets into Echinobase
Database J. Biol. Databases Curation, 2021 Echinobase (https://echinobase.org) is a central online platform that generates, manages and hosts genomic data relevant to echinoderm research. While the resource primarily serves the echinoderm research community, the recent release of an excellent ...
Saoirse Foley +6 more
semanticscholar +1 more source
PLoS ONE, 2014 Accurate orthology prediction is crucial for many applications in the post-genomic era. The lack of broadly accepted benchmark tests precludes a comprehensive analysis of orthology inference.
Kalliopi Trachana +6 more
doaj +1 more source
Microbial Cell, 2016 In order to combat the on-going malaria epidemic, discovery of new drug targets remains vital. Proteins that are essential to survival and specific to malaria parasites are key candidates.
January Weiner 3rd, Taco W.A. Kooij
doaj +1 more source
Proceedings of the ACM on Programming LanguagesWe study the proof theory and algorithms for orthologic, a logical system based on ortholattices, which have shown practical relevance in simplification and normalization of verification conditions. Ortholattices weaken Boolean algebras while having polynomial-time equivalence checking that is sound with respect to Boolean algebra semantics.
Guilloud, Simon, Kuncak, Viktor
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Logical Methods in Computer Science, 2017 We propose new sequent calculus systems for orthologic (also known as minimal quantum logic) which satisfy the cut elimination property. The first one is a simple system relying on the involutive status of negation. The second one incorporates the notion of focusing (coming from linear logic) to add constraints on proofs and to optimise proof search ...
openaire +7 more sources
Advanced Science, EarlyView.An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang +8 more
wiley +1 more source