Results 1 to 10 of about 18,885 (141)

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]

Journal of Virology, 2015
ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Amelia K Pinto, Graham D Williams, José Luiz Proença-módena   +2 more
exaly   +6 more sources

Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus) [PDF]

Journal of Medical Entomology, 2020
Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Nicole E. Breuner, Marvin S. Godsey, Angela M. Bosco-Lauth, Kristen L. Burkhalter, Harry M. Savage, Olga I. Kosoy, Dominic A Rose   +6 more
openaire   +4 more sources

DHORI VIRUS (ORTHOMYXOVIRIDAE: THOGOTOVIRUS) INFECTION IN MICE: A MODEL OF THE PATHOGENESIS OF SEVERE ORTHOMYXOVIRUS INFECTION [PDF]

The American Journal of Tropical Medicine and Hygiene, 2007
After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian influenza A virus.
Shu-Yuan Xiao, Hao Lei, Amelia P.A. Travassos Da Rosa, Robert B. Tesh, Rosa I. Mateo   +4 more
openaire   +4 more sources

Dhori Virus (Orthomyxoviridae: Thogotovirus) Infection of Mice Produces a Disease and Cytokine Response Pattern Similar to That of Highly Virulent Influenza A (H5N1) Virus Infection in Humans

The American Journal of Tropical Medicine and Hygiene, 2008
Mice infected with Dhori virus (DHOV) develop a fulminant, systemic, and uniformly fatal illness that has many of the clinical and pathologic findings seen in H5N1 influenza A virus infection. However, the role of host’s immune response in DHOV infection remains unclear. In this study, the concentrations of 23 inflammatory cytokines and chemokines were
Nan Wang, Robert B. Tesh, Chien-tek Tseng, Hilda Guzman, Tomoki Yoshikawa, Guangyu Li, Elena Sbrana, Shu-Yuan Xiao   +7 more
openaire   +4 more sources

Indirect Evidence of Bourbon Virus (Thogotovirus, Orthomyxoviridae) Infection in North Carolina [PDF]

North Carolina Medical Journal, 2020
Nicholas Komar, Nicholas Hamby, Carl Williams, Maria B. Palamar, J. Erin Staples   +4 more
openaire   +4 more sources

Reassortant Influenza A(H1N1)pdm09 Virus in Elderly Woman, Denmark, January 2021

Emerging Infectious Diseases, 2021
A case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark in January 2021. We describe the clinical case and report testing results
Jakob N. Nissen, Sophie J. George, Charlotte K. Hjulsager, Jesper S. Krog, Xiaohui C. Nielsen, Tina V. Madsen, Klara M. Andersen, Tyra G. Krause, Lasse S. Vestergaard, Lars E. Larsen, Ramona Trebbien   +10 more
doaj   +1 more source

Modulation of endothelial factors activity in human endothelial cells in influenza A(H1N1)pdm09 virus infection

Problems of Virology, 2021
Introduction. Influenza A virus infection can lead to endothelial dysfunction (ED), including apoptosis of endothelial cells and modulation of endothelial factor activities. Affected biochemical factors may include those playing important roles in vascular homeostasis.
V. A. Marchenko, S. V. Barashkova, I. A. Zelinskaya, Ya. G. Toropova, E. S. Ramsay, I. N. Zhilinskaya   +5 more
openaire   +4 more sources

Severe Human Case of Zoonotic Infection with Swine-Origin Influenza A Virus, Denmark, 2021

Emerging Infectious Diseases, 2022
During routine surveillance at the National Influenza Center, Denmark, we detected a zoonotic swine influenza A virus in a patient who became severely ill. We describe the clinical picture and the genetic characterization of this variant virus, which is
Klara M. Andersen, Lasse S. Vestergaard, Jakob N. Nissen, Sophie J. George, Pia Ryt-Hansen, Charlotte K. Hjulsager, Jesper S. Krog, Marianne N. Skov, Søren Alexandersen, Lars E. Larsen, Ramona Trebbien   +10 more
doaj   +1 more source

Comparative analysis of existing platforms for the development of vaccines against dangerous and extremely dangerous viral infections with pandemic potential

Биопрепараты: Профилактика, диагностика, лечение, 2021
The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko, T. E. Sizikova, V. N. Lebedev, S. V. Borisevich   +3 more
doaj   +1 more source

Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. [PDF]

PLoS Pathogens, 2010
The early host response to pathogens is mediated by several distinct pattern recognition receptors. Cytoplasmic RNA helicases including RIG-I and MDA5 have been shown to respond to viral RNA by inducing interferon (IFN) production.
Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J Holtzman, Marco Colonna   +6 more
doaj   +1 more source