Indirect Evidence of Bourbon Virus (Thogotovirus, Orthomyxoviridae) Infection in North Carolina [PDF]
North Carolina Medical Journal, 2020 To the Editor—Bourbon virus (Thogotovirus, Orthomyxoviridae) was discovered in 2014 when a patient with history of multiple tick bites in Kansas died from an unknown infection [1].
Nicholas, Komar +4 more
semanticscholar +4 more sources
Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]
Journal of Virology, 2015 ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Pinto, Amelia K +12 more
core +9 more sources
Mounting Evidence for an Expanded Host Range of Influenza B Viruses [PDF]
VirusesInfluenza B viruses (IBV) belong to the family of Orthomyxoviridae and circulate annually in humans causing respiratory illness. Although they are considered an exclusively human pathogen, there is evidence of IBV infections in animals, including ...
Marios Koutsakos +2 more
doaj +3 more sources
Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus) [PDF]
Journal of Medical Entomology, 2020 Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Marvin S, Godsey +6 more
openaire +3 more sources
Биопрепараты: Профилактика, диагностика, лечение, 2021 The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko +3 more
doaj +2 more sources
DHORI VIRUS (ORTHOMYXOVIRIDAE: THOGOTOVIRUS) INFECTION IN MICE: A MODEL OF THE PATHOGENESIS OF SEVERE ORTHOMYXOVIRUS INFECTION [PDF]
The American Journal of Tropical Medicine and Hygiene, 2007 After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian influenza A virus.
Rosa I, Mateo +4 more
openaire +3 more sources
Protective mechanism of quercetin and its derivatives in viral-induced respiratory illnesses
The Egyptian Journal of Bronchology, 2022 Globally, acute respiratory illnesses are the most commonly manifesting illness in all age group. The disease mostly affects the upper respiratory tract (URT) and is self-limiting.
Wahyu Choirur Rizky +2 more
doaj +2 more sources
Molecules, 2021 As a member of the Orthomyxoviridae family of viruses, influenza viruses (IVs) are known causative agents of respiratory infection in vertebrates. They remain a major global threat responsible for the most virulent diseases and global pandemics in humans.
Sphamadla E. Mtambo +7 more
doaj +2 more sources
Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. [PDF]
PLoS Pathogens, 2010 The early host response to pathogens is mediated by several distinct pattern recognition receptors. Cytoplasmic RNA helicases including RIG-I and MDA5 have been shown to respond to viral RNA by inducing interferon (IFN) production.
Leonid Gitlin +6 more
doaj +2 more sources
Pathogens, 2023 Influenza, a respiratory disease mainly caused by influenza A and B, viruses of the Orthomyxoviridae, is still a burden on our society’s health and economic system.
Martin C. Langenmayer +11 more
doaj +2 more sources