Results 1 to 10 of about 18,649 (175)

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]

Journal of Virology, 2015
ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Pinto, Amelia K, Williams, Graham D, Szretter, Kristy J, White, James P, Proença-Módena, José Luiz, Liu, Gai, Olejnik, Judith, Brien, James D, Ebihara, Hideki, Mühlberger, Elke, Amarasinghe, Gaya, Diamond, Michael S, Boon, Adrianus C.M.   +12 more
core   +9 more sources

Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus) [PDF]

Journal of Medical Entomology, 2020
Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Marvin S, Godsey, Dominic, Rose, Kristin L, Burkhalter, Nicole, Breuner, Angela M, Bosco-Lauth, Olga I, Kosoy, Harry M, Savage   +6 more
openaire   +3 more sources

DHORI VIRUS (ORTHOMYXOVIRIDAE: THOGOTOVIRUS) INFECTION IN MICE: A MODEL OF THE PATHOGENESIS OF SEVERE ORTHOMYXOVIRUS INFECTION [PDF]

The American Journal of Tropical Medicine and Hygiene, 2007
After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian influenza A virus.
Rosa I, Mateo, Shu-Yuan, Xiao, Hao, Lei, Amelia P A Travassos, DA Rosa, Robert B, Tesh   +4 more
openaire   +3 more sources

Mounting Evidence for an Expanded Host Range of Influenza B Viruses [PDF]

Viruses
Influenza B viruses (IBV) belong to the family of Orthomyxoviridae and circulate annually in humans causing respiratory illness. Although they are considered an exclusively human pathogen, there is evidence of IBV infections in animals, including ...
Marios Koutsakos, Rhys H. Parry, Michelle Wille   +2 more
doaj   +2 more sources

Endothelial protective properties of sacubitril-valsartan and drotaverine in influenza A(H1N1)pdm09 virus infection (<i>Orthomyxoviridae</i>: <i>Alphainfluenzavirus</i>: <i>influenza A virus</i>)

Problems of Virology
Introduction. Severe influenza is characterized by damage and morphofunctional changes of the endothelium of blood vessels, which contributes to the development of hemorrhagic syndrome and can cause endothelial dysfunction. To optimize the pathogenetic therapy of influenza infection, a screening of medications with endothelial protective properties was
Vladimir A. Marchenko, Irina A. Zelinskaya, Darya V. Mukhametdinova, Yana G. Toropova, Michael M. Galagudza, Irina N. Zhilinskaya   +5 more
openaire   +2 more sources

Expanding Horizons: Host Range Evolution and Treatment Strategies for Highly Pathogenic Avian Influenza H5N1 and H7N9 [PDF]

Viruses
Avian influenza viruses (AIVs), including H5N1 and H7N9, from the Orthomyxoviridae family present substantial public health concerns. The predominant circulating clade 2.3.4.4b has demonstrated enhanced capacity for mammalian adaptation, raising concerns
Nika Heidari Gazik, Mark Holodniy, Vafa Bayat   +2 more
doaj   +2 more sources

Indirect Evidence of Bourbon Virus (Thogotovirus, Orthomyxoviridae) Infection in North Carolina [PDF]

North Carolina Medical Journal, 2020
Nicholas, Komar, Nicholas, Hamby, Maria B, Palamar, J Erin, Staples, Carl, Williams   +4 more
openaire   +3 more sources

Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export [PDF]

Journal of Virology
Thogotoviruses are arthropod-borne viruses belonging to the genus Thogotovirus within the family Orthomyxoviridae. Like other orthomyxoviruses, such as the influenza A viruses (IAV), thogotoviruses replicate in the nucleus.
Vaille A. Swenson, Jack Hemsath, Iris Yousaf, Carla Weisend, Michael A. Barry, Hideki Ebihara, Satoko Yamaoka   +6 more
doaj   +2 more sources

Comprehensive characterization of non-retroviral endogenous viral elements in the rice pest Chilo suppressalis [PDF]

BMC Genomics
Background Non-retroviral endogenous viral elements (nrEVEs) are “molecular fossils” in eukaryotes that offer key molecular evidence into virus-host coevolution, particularly in insects.
Jia-Bao Lu, Yu-Hua Qi, Ying Tian, Qing-Kai Feng, Peng-Peng Ren, Hai-Jian Huang, Yi-Yuan Li, Jian-Ping Chen, Jun-Min Li, Chuan-Xi Zhang   +9 more
doaj   +2 more sources

Reassortant Influenza A(H1N1)pdm09 Virus in Elderly Woman, Denmark, January 2021

Emerging Infectious Diseases, 2021
A case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark in January 2021. We describe the clinical case and report testing results
Jakob N. Nissen, Sophie J. George, Charlotte K. Hjulsager, Jesper S. Krog, Xiaohui C. Nielsen, Tina V. Madsen, Klara M. Andersen, Tyra G. Krause, Lasse S. Vestergaard, Lars E. Larsen, Ramona Trebbien   +10 more
doaj   +1 more source