Results 41 to 50 of about 15,185 (134)

Endothelial protective properties of sacubitril-valsartan and drotaverine in influenza A(H1N1)pdm09 virus infection (<i>Orthomyxoviridae</i>: <i>Alphainfluenzavirus</i>: <i>influenza A virus</i>)

Problems of Virology
Introduction. Severe influenza is characterized by damage and morphofunctional changes of the endothelium of blood vessels, which contributes to the development of hemorrhagic syndrome and can cause endothelial dysfunction. To optimize the pathogenetic therapy of influenza infection, a screening of medications with endothelial protective properties was
Vladimir A. Marchenko, Irina A. Zelinskaya, Darya V. Mukhametdinova, Yana G. Toropova, Michael M. Galagudza, Irina N. Zhilinskaya   +5 more
openaire   +1 more source

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, Volume 13, Issue 26, 8 May 2026.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Natural Extracts as Candidate Influenza Vaccine Adjuvants. Seasonal influenza vaccines face limitations due to viral mutations and low efficacy in vulnerable populations. Traditional adjuvants often have safety or immune‐activation constraints, leading to increased interest in natural extracts from plants, marine organisms, and fungi.
Thi Len Ho, Eun‐Ju Ko
wiley   +1 more source

Development and Qualification of a Pseudotyped Virus‐Based Microneutralisation Assay for Influenza D Virus

Influenza and Other Respiratory Viruses, Volume 20, Issue 4, April 2026.
ABSTRACT Background Epidemiological surveillance of influenza D virus (IDV) has gained increased priority following recent serological findings indicating its potential zoonosis in humans. In this context, it is crucial to develop strong, reproducible, reliable and scalable immunological assays that can be quickly implemented in the surveillance of new
Maria Giovanna Marotta, Tobias Mapulanga, Meshach Maina, Janet Daly, Michele Camero, Pauline Mvan Diemen, Helen E. Everett, Emanuele Montomoli, Kelly da Costa, Nigel Temperton, Claudia Maria Trombetta   +10 more
wiley   +1 more source

Monitoring Silent Spillovers Before Emergence: A Pilot Study at the Tick/Human Interface in Thailand

Frontiers in Microbiology, 2019
Emerging zoonoses caused by previously unknown agents are one of the most important challenges for human health because of their inherent inability to be predictable, conversely to emergences caused by previously known agents that could be targeted by ...
Sarah Temmam, Delphine Chrétien, Thomas Bigot, Thomas Bigot, Evelyne Dufour, Stéphane Petres, Marc Desquesnes, Marc Desquesnes, Marc Desquesnes, Elodie Devillers, Marine Dumarest, Léna Yousfi, Sathaporn Jittapalapong, Anamika Karnchanabanthoeng, Kittipong Chaisiri, Léa Gagnieur, Jean-François Cosson, Muriel Vayssier-Taussat, Serge Morand, Serge Morand, Sara Moutailler, Marc Eloit, Marc Eloit   +22 more
doaj   +1 more source

Indirect Evidence of Bourbon Virus (Thogotovirus, Orthomyxoviridae) Infection in North Carolina [PDF]

North Carolina Medical Journal, 2020
Nicholas, Komar, Nicholas, Hamby, Maria B, Palamar, J Erin, Staples, Carl, Williams   +4 more
openaire   +2 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

A compendium of multi-omics data illuminating host responses to lethal human virus infections

Scientific Data
Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death.
Amie J. Eisfeld, Lindsey N. Anderson, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff Smith, Larissa B. Thackray, Qing Tan, Amy C. Sims, Vineet D. Menachery, Alexandra Schäfer, Timothy P. Sheahan, Adam S. Cockrell, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Young-Mo Kim, Carrie D. Nicora, Zuleyma Peralta, Alhaji U. N’jai, Foday Sahr, Harm van Bakel, Michael S. Diamond, Ralph S. Baric, Thomas O. Metz, Richard D. Smith, Yoshihiro Kawaoka, Katrina M. Waters   +28 more
doaj   +1 more source

Development of eNA Sampling for Early Detection of Pathogens in On‐Farm Water Sources

Environmental DNA, Volume 8, Issue 2, March/April 2026.
We compare four water‐sampling methods for detecting microbial and viral eNA in livestock troughs and show all approaches effectively recover community profiles, supporting flexible, field‐ready surveillance of livestock pathogens. ABSTRACT Early detection of livestock pathogens is critical for mitigating risk and implementing timely control or ...
Maxine P. Piggott, Allyson Malpartida
wiley   +1 more source