Results 51 to 60 of about 15,185 (134)

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source

Drivers of Viral Diversity and Sharing in Marine Mammals

Molecular Ecology, Volume 35, Issue 6, March 2026.
ABSTRACT Knowledge of viral infection in marine mammals, a group severely threatened by human activity, is largely limited to the pathology and epidemiology of few endemic viruses. The recent emergence in marine mammals of high‐consequence viruses, such as H5N1 avian influenza and rabies, underscores the importance of understanding the ecology of viral
Matthew J. Arnold, Laura M. Bergner, Haris Malik, Mariel ten Doeschate, Nicholas J. Davison, Andrew Brownlow, Nardus Mollentze, Simon A. Babayan, Daniel G. Streicker   +8 more
wiley   +1 more source

Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection.

PLoS Pathogens
Flaviviridae viruses constitute formidable zoonotic agents with substantial global health and economic ramifications, attributable to their adeptness at circumventing host immune surveillance and establishing persistent infections across human and animal
Jing Chen, Lin Han Zhong, Jin Xia Chen, Hui Xin Song, Lin Ke Zou, Xiao Qing Bi, Bing Qian Zhao, Mei Zhen Li, Kun Li, Kang Wang, Jia Jun Yang, Jin Cui, Li Wang, Bin Zhou   +13 more
doaj   +1 more source

Virological Passive Surveillance of Avian Influenza and Arboviruses in Wild Birds: A Two-Year Study (2023–2024) in Lombardy, Italy

Microorganisms
Avian influenza (AI), caused by Alphainfluenzavirus (family Orthomyxoviridae), poses significant threats to poultry, biodiversity, and public health.
Maria Cristina Rapi, Ana Maria Moreno Martin, Davide Lelli, Antonio Lavazza, Stefano Raimondi, Marco Farioli, Mario Chiari, Guido Grilli   +7 more
doaj   +1 more source

Infectious salmon anaemia virus (ISAV) isolated from the ISA disease outbreaks in Chile diverged from ISAV isolates from Norway around 1996 and was disseminated around 2005, based on surface glycoprotein gene sequences

Virology Journal, 2009
Background Infectious salmon anaemia (ISA) virus (ISAV) is a pathogen of marine-farmed Atlantic salmon (Salmo salar); a disease first diagnosed in Norway in 1984.
Lisperger Angelica, Mansilla Soledad, Gherardelli Valentina, Kibenge Molly JT, Godoy Marcos G, Wang Yingwei, Kibenge Frederick SB, Jarpa Miguel, Larroquete Geraldine, Avendaño Fernando, Lara Marcela, Gallardo Alicia   +11 more
doaj   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Zoonosis and zooanthroponosis of emerging respiratory viruses

Frontiers in Cellular and Infection Microbiology
Lung infections in Influenza-Like Illness (ILI) are triggered by a variety of respiratory viruses. All human pandemics have been caused by the members of two major virus families, namely Orthomyxoviridae (influenza A viruses (IAVs); subtypes H1N1, H2N2 ...
Ahmed Magdy Khalil, Ahmed Magdy Khalil, Luis Martinez-Sobrido, Ahmed Mostafa, Ahmed Mostafa   +4 more
doaj   +1 more source

Avian influenza virus H5N1 and H9N2 subtypes in different birds and humans: Findings from an extensive evaluation

Open Veterinary Journal
The H5N1 and H9N2 subtypes of the avian influenza virus (AIV), part of the Orthomyxoviridae family, induce one of the most severe zoonotic diseases.
Saifur Rehman, Shakeeb Ullah, Mustofa Helmi Effendi, Budiastuti Budiastuti, Iwan Sahrial Hamid, Atta Ur Rahman, Ali Zaman, Muhammad Inam Ullah Malik, Saqib Ali Rustam, Sana Ullah, Zulqarnain Saleem   +10 more
doaj   +1 more source

Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus

Bioengineering
Despite the seriousness of the disease carried by ticks, little is known about the Bourbon virus. Only three US states have recorded human cases of Bourbon virus (BRBV) infection; in all cases, a tick bite was connected with the onset of the illness. The
Taghreed N. Almanaa
doaj   +1 more source

EPIDEMIOLOGICAL ANALYSIS OF AVIAN INFLUENZA IN THE AMERICAS WITH EMPHASIS ON BRAZIL: PAHO DATA FROM 2024 TO THE 25TH EPIDEMIOLOGICAL WEEK OF 2025

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Avian influenza is caused by viruses of the Orthomyxoviridae family and primarily affects birds, and in some cases can infect humans.
Roberta Maduro Prado, Beatriz Marcondes Framil de Souza, Renato Augusto Passos   +2 more
doaj   +1 more source