Results 61 to 70 of about 18,794 (175)

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

The interplay of co-infections in shaping COVID-19 severity: Expanding the scope beyond SARS-CoV-2

Journal of Infection and Public Health
High mortality has been reported in severe cases of COVID-19. Emerging reports suggested that the severity is not only due to SARS-CoV-2 infection, but also due to coinfections by other pathogens exhibiting symptoms like COVID-19.
Budhadev Baral, Vaishali Saini, Meenakshi Kandpal, Pratik Kundu, Amit Kumar Dixit, Hamendra Singh Parmar, Ajay Kumar Meena, Pankaj Trivedi, Hem Chandra Jha   +8 more
doaj   +1 more source

Patent Landscape of Influenza A Virus Prophylactic Vaccines and Related Technologies [PDF]

, 2012
Executive Summary: This report focuses on patent landscape analysis of technologies related to prophylactic vaccines targeting pandemic strains of influenza.
Barton, Jeremy, Cavicchi, Jon R., Janovetz, Jeffrey, Kowalski, Stanley P., Pflugh, David L., Schroeder, John   +5 more
core   +1 more source

Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses [PDF]

, 2012
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus.
Cruciani, Gabriele, Digard, Paul, Goracci, Laura, Loregian, Arianna, Mercorelli, Beatrice, Muratore, Giulia, Palu, Giorgio   +6 more
core   +2 more sources

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, Volume 13, Issue 26, 8 May 2026.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]

, 2014
Mammals express the sialic acids ​N-acetylneuraminic acid (​Neu5Ac) and ​N-glycolylneuraminic acid (​Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). ​Neu5Gc is synthesized from ​Neu5Ac by the enzyme
Böhm, Raphael, Coloe, Peter J., Grimmond, Sean M., Hartley-Tassell, Lauren E., Haselhorst, Thomas, Hawthorne, Paula L., Jennings, Michael P., Lukowski, Samuel W., Ng, Preston S.K., Paton, Adrienne W., Paton, James C., Steen, Jason A., Trezise, Ann E.O., von Itzstein, Mark, Wang, Hui   +14 more
core   +1 more source

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Natural Extracts as Candidate Influenza Vaccine Adjuvants. Seasonal influenza vaccines face limitations due to viral mutations and low efficacy in vulnerable populations. Traditional adjuvants often have safety or immune‐activation constraints, leading to increased interest in natural extracts from plants, marine organisms, and fungi.
Thi Len Ho, Eun‐Ju Ko
wiley   +1 more source

Influenza d virus infection in herd of cattle, Japan [PDF]

, 2016
Citation: Murakami, S., Endoh, M., Kobayashi, T., Takenaka-Uema, A., Chambers, J. K., Uchida, K., . . . Horimoto, T. (2016). Influenza d virus infection in herd of cattle, Japan. Emerging Infectious Diseases, 22(8), 1517-1519.
Chambers, J. K., Endoh, M., Hause, Benjamin M., Horimoto, T., Kobayashi, T., Murakami, S., Nishihara, M., Takenaka-Uema, A., Uchida, K.   +8 more
core   +2 more sources

Development and Qualification of a Pseudotyped Virus‐Based Microneutralisation Assay for Influenza D Virus

Influenza and Other Respiratory Viruses, Volume 20, Issue 4, April 2026.
ABSTRACT Background Epidemiological surveillance of influenza D virus (IDV) has gained increased priority following recent serological findings indicating its potential zoonosis in humans. In this context, it is crucial to develop strong, reproducible, reliable and scalable immunological assays that can be quickly implemented in the surveillance of new
Maria Giovanna Marotta, Tobias Mapulanga, Meshach Maina, Janet Daly, Michele Camero, Pauline Mvan Diemen, Helen E. Everett, Emanuele Montomoli, Kelly da Costa, Nigel Temperton, Claudia Maria Trombetta   +10 more
wiley   +1 more source

Endothelial protective properties of sacubitril-valsartan and drotaverine in influenza A(H1N1)pdm09 virus infection (<i>Orthomyxoviridae</i>: <i>Alphainfluenzavirus</i>: <i>influenza A virus</i>)

Problems of Virology
Introduction. Severe influenza is characterized by damage and morphofunctional changes of the endothelium of blood vessels, which contributes to the development of hemorrhagic syndrome and can cause endothelial dysfunction. To optimize the pathogenetic therapy of influenza infection, a screening of medications with endothelial protective properties was
Vladimir A. Marchenko, Irina A. Zelinskaya, Darya V. Mukhametdinova, Yana G. Toropova, Michael M. Galagudza, Irina N. Zhilinskaya   +5 more
openaire   +1 more source