Results 11 to 20 of about 1,027,051 (159)

The interplay of co-infections in shaping COVID-19 severity: Expanding the scope beyond SARS-CoV-2

Journal of Infection and Public Health
High mortality has been reported in severe cases of COVID-19. Emerging reports suggested that the severity is not only due to SARS-CoV-2 infection, but also due to coinfections by other pathogens exhibiting symptoms like COVID-19.
Budhadev Baral, Vaishali Saini, Meenakshi Kandpal, Pratik Kundu, Amit Kumar Dixit, Hamendra Singh Parmar, Ajay Kumar Meena, Pankaj Trivedi, Hem Chandra Jha   +8 more
doaj   +2 more sources

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

Cell Reports
Summary: Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans.
Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Veronica Duran, Michele Donato, Mario Roederer, Megha Kamath, John-Paul M. Todd, Matthew Gagne, Kathryn E. Foulds, Joseph R. Francica, Kizzmekia S. Corbett, Daniel C. Douek, Robert A. Seder, Shirit Einav, Catherine A. Blish, Purvesh Khatri   +17 more
doaj   +2 more sources

Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. [PDF]

PLoS Pathogens, 2010
The early host response to pathogens is mediated by several distinct pattern recognition receptors. Cytoplasmic RNA helicases including RIG-I and MDA5 have been shown to respond to viral RNA by inducing interferon (IFN) production.
Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J Holtzman, Marco Colonna   +6 more
doaj   +1 more source

Protective mechanism of quercetin and its derivatives in viral-induced respiratory illnesses

The Egyptian Journal of Bronchology, 2022
Globally, acute respiratory illnesses are the most commonly manifesting illness in all age group. The disease mostly affects the upper respiratory tract (URT) and is self-limiting.
Wahyu Choirur Rizky, Muhammad Candragupta Jihwaprani, Mazhar Mushtaq   +2 more
doaj   +1 more source

2023-06-14 - NCBI Viruses - Orthomyxoviridae

, 2023
Orthomyxoviridae sequences from the NCBI FTP site (https://ftp.ncbi.nlm.nih.gov/genomes/Viruses/AllNucleotide/) (downloaded 2023-06-14). Metadata from AllNuclMetadata.csv.gz (https://ftp.ncbi.nlm.nih.gov/genomes/Viruses/AllNuclMetadata/) dropping certain
Peter Kruczkiewicz (5422523)
core   +1 more source

Comparative analysis of existing platforms for the development of vaccines against dangerous and extremely dangerous viral infections with pandemic potential

Биопрепараты: Профилактика, диагностика, лечение, 2021
The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko, T. E. Sizikova, V. N. Lebedev, S. V. Borisevich   +3 more
doaj   +1 more source

Influenza Viruses: Harnessing the Crucial Role of the M2 Ion-Channel and Neuraminidase toward Inhibitor Design

Molecules, 2021
As a member of the Orthomyxoviridae family of viruses, influenza viruses (IVs) are known causative agents of respiratory infection in vertebrates. They remain a major global threat responsible for the most virulent diseases and global pandemics in humans.
Sphamadla E. Mtambo, Daniel G. Amoako, Anou M. Somboro, Clement Agoni, Monsurat M. Lawal, Nelisiwe S. Gumede, Rene B. Khan, Hezekiel M. Kumalo   +7 more
doaj   +1 more source

Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile

Emerging Infectious Diseases, 2004
Influenza A viruses occur worldwide in wild birds and are occasionally associated with outbreaks in commercial chickens and turkeys. However, avian influenza viruses have not been isolated from wild birds or poultry in South America. A recent outbreak in
David L. Suarez, Dennis A. Senne, Jill Banks, Ian H. Brown, Steve C. Essen, Chang-Won Lee, Ruth J. Manvell, Christian Mathieu-Benson, Valentine Moreno, Janice C. Pedersen, Brundaban Panigrahy, Herman Rojas, Eric Spackman, Dennis J. Alexander   +13 more
doaj   +1 more source

H1N1 Virus Production and Infection

Bio-Protocol, 2018
Influenza A virus is a member of orthomyxoviridae family causing wide-spread infections in human respiratory tract. Mouse infection model is widely used in antiviral research and pathogenesis study against influenza A virus. Here, we report a protocol in
Binbin Zhao, Jiaoyu Shan, Rui Xiong, Ke Xu, Bin Li   +4 more
doaj   +1 more source

Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing. [PDF]

PLoS ONE, 2012
The human respiratory tract is heavily exposed to microorganisms. Viral respiratory tract pathogens, like RSV, influenza and rhinoviruses cause major morbidity and mortality from respiratory tract disease.
Fredrik Lysholm, Anna Wetterbom, Cecilia Lindau, Hamid Darban, Annelie Bjerkner, Kristina Fahlander, A Michael Lindberg, Bengt Persson, Tobias Allander, Björn Andersson   +9 more
doaj   +1 more source