Results 11 to 20 of about 18,794 (175)

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]

Journal of Virology, 2015
ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Pinto, Amelia K, Williams, Graham D, Szretter, Kristy J, White, James P, Proença-Módena, José Luiz, Liu, Gai, Olejnik, Judith, Brien, James D, Ebihara, Hideki, Mühlberger, Elke, Amarasinghe, Gaya, Diamond, Michael S, Boon, Adrianus C.M.   +12 more
openaire   +8 more sources

Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]

Small Sci
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc   +2 more sources

Mounting Evidence for an Expanded Host Range of Influenza B Viruses [PDF]

Viruses
Influenza B viruses (IBV) belong to the family of Orthomyxoviridae and circulate annually in humans causing respiratory illness. Although they are considered an exclusively human pathogen, there is evidence of IBV infections in animals, including ...
Marios Koutsakos, Rhys H. Parry, Michelle Wille   +2 more
doaj   +2 more sources

Expanding Horizons: Host Range Evolution and Treatment Strategies for Highly Pathogenic Avian Influenza H5N1 and H7N9 [PDF]

Viruses
Avian influenza viruses (AIVs), including H5N1 and H7N9, from the Orthomyxoviridae family present substantial public health concerns. The predominant circulating clade 2.3.4.4b has demonstrated enhanced capacity for mammalian adaptation, raising concerns
Nika Heidari Gazik, Mark Holodniy, Vafa Bayat   +2 more
doaj   +2 more sources

Comprehensive characterization of non-retroviral endogenous viral elements in the rice pest Chilo suppressalis [PDF]

BMC Genomics
Background Non-retroviral endogenous viral elements (nrEVEs) are “molecular fossils” in eukaryotes that offer key molecular evidence into virus-host coevolution, particularly in insects.
Jia-Bao Lu, Yu-Hua Qi, Ying Tian, Qing-Kai Feng, Peng-Peng Ren, Hai-Jian Huang, Yi-Yuan Li, Jian-Ping Chen, Jun-Min Li, Chuan-Xi Zhang   +9 more
doaj   +2 more sources

Metagenomic sequencing reveals viral diversity of mosquitoes from Egypt: co-circulation of multiple insect-specific viruses [PDF]

Microbiology Spectrum
Mosquito-borne virus surveillance is pivotal for investigating mosquito viromes, facilitating understanding of viral evolutionary histories and genetic diversity. Natural viral communities in mosquitoes include not only insect-specific viruses (ISVs) but
Shenglin Chen, Yuanyuan Li, Jinbo Xue, Yuwan Hao, Mona G. A. Shaalan, Enas H. S. Ghallab, Zhaoyu Guo, Shuqing Jin, Yuan Fang, Emad I. M. Khater, Shizhu Li   +10 more
doaj   +2 more sources

Lethal Case of Bourbon Virus Leading to Shock and ECMO Utilization. [PDF]

Case Rep Infect Dis
We present a lethal case of Bourbon virus infection in a 63‐year‐old Caucasian, diabetic male who was previously in good health. The patient had spent time in the wooded areas of Bourbon County, Kansas, and removed three ticks from his body 5 days prior to presentation.
Mitchell A, Gessouroun A, Atrouni WE, Kubat R, Almoghrabi O, Vorhies M, Flynn B.   +6 more
europepmc   +2 more sources

Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export [PDF]

Journal of Virology
Thogotoviruses are arthropod-borne viruses belonging to the genus Thogotovirus within the family Orthomyxoviridae. Like other orthomyxoviruses, such as the influenza A viruses (IAV), thogotoviruses replicate in the nucleus.
Vaille A. Swenson, Jack Hemsath, Iris Yousaf, Carla Weisend, Michael A. Barry, Hideki Ebihara, Satoko Yamaoka   +6 more
doaj   +2 more sources

Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus) [PDF]

Journal of Medical Entomology, 2020
Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Marvin S, Godsey, Dominic, Rose, Kristin L, Burkhalter, Nicole, Breuner, Angela M, Bosco-Lauth, Olga I, Kosoy, Harry M, Savage   +6 more
openaire   +2 more sources

Reassortant Influenza A(H1N1)pdm09 Virus in Elderly Woman, Denmark, January 2021

Emerging Infectious Diseases, 2021
A case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark in January 2021. We describe the clinical case and report testing results
Jakob N. Nissen, Sophie J. George, Charlotte K. Hjulsager, Jesper S. Krog, Xiaohui C. Nielsen, Tina V. Madsen, Klara M. Andersen, Tyra G. Krause, Lasse S. Vestergaard, Lars E. Larsen, Ramona Trebbien   +10 more
doaj   +1 more source