Results 11 to 20 of about 18,603 (173)
Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]
Small SciNanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc +2 more sources
Lethal Case of Bourbon Virus Leading to Shock and ECMO Utilization. [PDF]
Case Rep Infect DisWe present a lethal case of Bourbon virus infection in a 63‐year‐old Caucasian, diabetic male who was previously in good health. The patient had spent time in the wooded areas of Bourbon County, Kansas, and removed three ticks from his body 5 days prior to presentation.
Mitchell A +6 more
europepmc +2 more sources
Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. [PDF]
PLoS Pathogens, 2010 The early host response to pathogens is mediated by several distinct pattern recognition receptors. Cytoplasmic RNA helicases including RIG-I and MDA5 have been shown to respond to viral RNA by inducing interferon (IFN) production.
Leonid Gitlin +6 more
doaj +1 more source
Severe Human Case of Zoonotic Infection with Swine-Origin Influenza A Virus, Denmark, 2021
Emerging Infectious Diseases, 2022 During routine surveillance at the National Influenza Center, Denmark, we detected a zoonotic swine influenza A virus in a patient who became severely ill. We describe the clinical picture and the genetic characterization of this variant virus, which is
Klara M. Andersen +10 more
doaj +1 more source
Protective mechanism of quercetin and its derivatives in viral-induced respiratory illnesses
The Egyptian Journal of Bronchology, 2022 Globally, acute respiratory illnesses are the most commonly manifesting illness in all age group. The disease mostly affects the upper respiratory tract (URT) and is self-limiting.
Wahyu Choirur Rizky +2 more
doaj +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2021 The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko +3 more
doaj +1 more source
An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. [PDF]
, 2016 Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated
Chen, Xi +8 more
core +7 more sources
Molecules, 2021 As a member of the Orthomyxoviridae family of viruses, influenza viruses (IVs) are known causative agents of respiratory infection in vertebrates. They remain a major global threat responsible for the most virulent diseases and global pandemics in humans.
Sphamadla E. Mtambo +7 more
doaj +1 more source
Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile
Emerging Infectious Diseases, 2004 Influenza A viruses occur worldwide in wild birds and are occasionally associated with outbreaks in commercial chickens and turkeys. However, avian influenza viruses have not been isolated from wild birds or poultry in South America. A recent outbreak in
David L. Suarez +13 more
doaj +1 more source
Therapeutic efficacy of favipiravir against Bourbon virus in mice [PDF]
, 2019 Bourbon virus (BRBV) is an emerging tick-borne RNA virus in the orthomyxoviridae family that was discovered in 2014. Although fatal human cases of BRBV have been described, little is known about its pathogenesis, and no antiviral therapies or vaccines ...
Bailey, Thomas +11 more
core +3 more sources