The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li+12 more
wiley +1 more source
Visual Attention Based Cognitive Human-Robot Collaboration for Pedicle Screw Placement in Robot-Assisted Orthopedic Surgery [PDF]
Current orthopedic robotic systems largely focus on navigation, aiding surgeons in positioning a guiding tube but still requiring manual drilling and screw placement. The automation of this task not only demands high precision and safety due to the intricate physical interactions between the surgical tool and bone but also poses significant risks when ...
arxiv +1 more source
Osseointegrated prostheses for rehabilitation following amputation : The pioneering Swedish model. [PDF]
The direct attachment of osseointegrated (OI) prostheses to the skeleton avoids the inherent problems of socket suspension. It also provides physiological weight bearing, improved range of motion in the proximal joint, as well as osseoperceptive sensory ...
Brånemark, Rickard, Li, Yan
core +1 more source
Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang+18 more
wiley +1 more source
Effect of a Habitual Late-Evening Physical Task on Sleep Quality in Neither-Type Soccer Players
Purpose: The aim of this study was to investigate objective and subjective sleep quality, daytime tiredness and sleepiness in response to a late-evening high intensity interval training (HIIT) session in neither-type soccer players that habitually ...
Jacopo A. Vitale+5 more
doaj +1 more source
Finite element analysis of porously punched prosthetic short stem virtually designed for simulative uncemented hip arthroplasty [PDF]
Background: There is no universal hip implant suitably fills all femoral types, whether prostheses of porous short-stem suitable for Hip Arthroplasty is to be measured scientifically.
Bai, Bo+4 more
core +2 more sources
Genetics‐Based Targeting Strategies for Precise Neuromodulation
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He+11 more
wiley +1 more source
Methodical Approach for Determining the Length of Drill Channels in Osteosynthesis
In order to fix a fracture in osteosynthesis, it is necessary to attach screws bicortically to the bone. The length of the screws must be selected correctly in 1-mm increments: otherwise, injury to the surrounding tissue structure or insufficient ...
Michael Sorg+2 more
doaj +1 more source
Composer: Visual Cohort Analysis of Patient Outcomes [PDF]
Objective: Visual cohort analysis utilizing electronic health record data has become an important tool in clinical assessment of patient outcomes. In this paper, we introduce Composer, a visual analysis tool for orthopedic surgeons to compare changes in physical functions of a patient cohort following various spinal procedures.
arxiv
The clinical features of the piriformis syndrome: a systematic review [PDF]
Piriformis syndrome, sciatica caused by compression of the sciatic nerve by the piriformis muscle, has been described for over 70 years; yet, it remains controversial. The literature consists mainly of case series and narrative reviews. The objectives of
A Chantraine+117 more
core +2 more sources