Results 141 to 150 of about 7,142 (165)

Animal Models of Orthopoxvirus Infection

Veterinary Pathology, 2010
Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of Orthopoxvirus could be used as agents of bioterrorism. Therefore,
J L, Chapman, D K, Nichols, M J, Martinez, J W, Raymond   +3 more
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Genus Orthopoxvirus: Monkeypox virus

2007
Monkeypox virus is an orthopoxvirus that is genetically distinct from other members of the genus, including Variola virus, Vaccinia virus, Ectromelia virus, Camelpox virus, and Cowpox virus. It was first identified as the cause of a pox-like illness in captive monkeys in 1958.
Sandra Essbauer, Hermann Meyer
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Genus Orthopoxvirus: Cowpox virus

2007
Cowpox virus (CPXV) is distinguished from other orthopoxvirus (OPV) species by producing cytoplasmic A-type inclusion bodies and flattened pocks with a hemorrhagic center on the chorioallantoic membrane. CPXV is endemic to Western Eurasia and naturally infects a broad range of host species including domestic animals, and zoo animals, as well as humans.
Sandra Essbauer, Hermann Meyer
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Smallpox and Other Orthopoxvirus Diseases

VacciTUTOR, 2022
Smallpox was a severe disease causing substantial mortality among populations over several thousand years. It is caused by an orthopoxvirus, the variola (= smallpox) virus. Smallpox is a febrile disease with a maculo-, papulo-, vesicular and finally pustular rash, the typical pox lesions, numerous complications and a fatality rate of approximately 30%.
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Pharmacological Review on Orthopoxvirus

Research Journal of Pharmacology and Pharmacodynamics
Monkeypox is an emerging viral zoonotic disease caused by the monkeypox virus, which is particularly significant as it is endemic to Central and Western Africa. This disease is rare and manifests with a rash resembling that of smallpox. However, its transmission between individuals beyond close contact is limited, and the case fatality rates for ...
P. Devi Guna Sireesha, Sameer Shaik, Shabreen Begum Shaik, Khadar Basha Showkath Basha, Mubina Begum Shaik   +4 more
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Regulation of Orthopoxvirus Gene Expression

1990
Poxviruses differ from the other major groups of DNA viruses with regard to their use of the cytoplasm, rather than the nucleus, as the site of transcription. Consistent with this strategy, poxviruses encode their own DNA-dependent RNA polymerase as well as many—if not all—of the additional enzymes and factors needed to synthesize functional capped ...
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Orthopoxvirus vaccines and vaccination

2007
Immunization procedures against Variola virus, from the historical perspective most often first credited to Edward Jenner in the late 18th century, helped finally to eradicate smallpox from the world. Since its eradication, the study of this disease and its pathology has been given little attention; however, with the emergence of Monkeypox virus into ...
Lauren M. Handley, J. Paige Mackey, R. Mark Buller, Clifford J. Bellone   +3 more
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Orthopoxvirus Purification for High Containment Laboratories

Purification of large viruses in a high containment laboratory can create unique challenges. Traditional purification methods for large viruses rely on equipment and techniques that are not ideal for high containment work. Poxvirus purification has long relied on the use of Genetron®, a reagent that is no longer available.
Laura, Hughes, Kimberly, Wilkins, Scott, Smith, Victoria A, Olson, Panayampalli Subbian, Satheshkumar   +4 more
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Mouse Models for Studying Orthopoxvirus Respiratory Infections

2004
Concern regarding the use of variola and monkeypox viruses as bioterrorist agents has led to an increased study of orthopoxviruses to understand the molecular and cellular basis of pathogenesis and develop safe and effective antivirals and vaccines against smallpox.
Jill, Schriewer, R Mark L, Buller, Gelita, Owens   +2 more
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Inactivation of orthopoxvirus for diagnostic PCR analysis

Journal of Virological Methods, 2007
Diagnoses of ongoing viral infections commonly rely on PCR methodology. Sample material that may contain hazardous virus should be efficiently inactivated in biological containment or bed-side before diagnostic PCR analysis. Surprisingly little documentation is available for inactivation of human viral pathogens by inactivation reagents that allow for ...
Lasse, Vinner, Anders, Fomsgaard
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