Results 121 to 130 of about 9,580 (245)

Understanding orthopoxvirus host range and evolution: from the enigmatic to the usual suspects.

Current Opinion in Virology, 2018
In general, orthopoxviruses can be considered as falling into one of three host-utilization categories: highly specialized, single-host; broad host range; or 'cryptic', the last encompassing those viruses about which very little is known.
M. Reynolds, S. Guagliardo, Y. Nakazawa, Jeffrey B Doty, Matthew R. Mauldin   +4 more
semanticscholar   +1 more source

Human Monkeypox in Sierra Leone after 44-Year Absence of Reported Cases

Emerging Infectious Diseases, 2019
We note the reemergence of human monkeypox in Sierra Leone following a 44-year absence of reported disease. The persons affected were an 11-month-old boy and, several years later, a 35-year-old man.
Mary G. Reynolds, Nadia Wauquier, Yu Li, Panayampalli Subbian Satheshkumar, Lansana D. Kanneh, Benjamin Monroe, Jacob Maikere, Gbessay Saffa, Jean-Paul Gonzalez, Joseph Fair, Darin S. Carroll, Amara Jambai, Foday Dafae, Sheik Humarr Khan, Lina M. Moses   +14 more
doaj   +1 more source

Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose

Journal of Translational Medicine, 2018
Pancreatic ductal adenocarcinoma (PDAC) has been increasing by 0.5% per year in the United States. PDAC portends a dismal prognosis and novel therapies are needed.
M. O'Leary, A. Choi, Sang-In Kim, S. Chaurasiya, Jianming Lu, Anthony K. Park, Y. Woo, S. Warner, Y. Fong, N. Chen   +9 more
semanticscholar   +1 more source

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides:  Identification of Novel Orthopoxvirus Egress Inhibitors

, 2016
A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection.
Marc S. Collett (2497417), Earl R. Kern (2497402), Gerry Rhodes (2497420), Christopher J. Burns (685703), Daniel C. Pevear (2497423), Robert Jordan (346146), Robert O. Baker (2497408), Thomas R. Bailey (2497399), John W. Huggins (202153), Kathy A. Keith (2497426), Sanjeev Tohan (2497405), Dennis Hruby (2497396), Susan R. Rippin (1443640), Dongcheng Dai (2497414), Elizabeth Opsitnick (2497411), Guang Yang (154978)   +15 more
core   +1 more source

Fatal outbreak in Tonkean macaques caused by possibly novel Orthopoxvirus, Italy, January 2015 [PDF]

, 2017
In January 2015, during a 3-week period, 12 captive Tonkean macacques at a sanctuary in Italy died. An orthopoxvirus infection was suspected because of negative-staining electron microscopy results.
Scicluna, M. T., Cesare Ernesto Maria Gruber, Vincenzo Puro, Di Caro, A., Maria Teresa Scicluna, Gruber, C. E. M., Carletti, F., Rosone, F., Daniele Lapa, Giusy Cardeti, Fabrizio Carletti, Lorenzo De Marco, Claudia Eleni, Manna, G., Giombini, E., Antonino Di Caro, Maria Rosaria Capobianchi, Marina Selleri, Cardeti, G., Raniero Lorenzetti, Autorino, G. L., De Marco, L., Selleri, M., Emanuela Giombini, Grifoni, G., Eleni, C., Capobianchi, M. R., Francesca Rosone, Goffredo Grifoni, Gian Luca Autorino, Concetta Castilletti, Valentina Tagliapietra, Lorenzetti, R., Tagliapietra, V., Lapa, D., Giuseppe Manna, Castilletti, C., Puro, V., Rizzoli, A., Annapaola Rizzoli   +39 more
core   +1 more source

CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development

Viruses, 2018
The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches.
Arinze S. Okoli, M. I. Okeke, M. Tryland, U. Moens   +3 more
semanticscholar   +1 more source

Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease

Microbiology Spectrum
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak.
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker   +17 more
doaj   +1 more source

Orthopoxvirus species and strain differences in cell entry

Virology, 2012
Vaccinia virus (VACV) enters cells by a low pH endosomal route or by direct fusion with the plasma membrane. We previously found differences in entry properties of several VACV strains: entry of WR was enhanced by low pH, reduced by bafilomycin A1 and relatively unaffected by heparin, whereas entry of IHD-J, Copenhagen and Elstree were oppositely ...
Bengali, Zain, Satheshkumar, P.S., Moss, Bernard   +2 more
openaire   +2 more sources

Effective Antiviral Treatment of Systemic Orthopoxvirus Disease: ST-246 Treatment of Prairie Dogs Infected with Monkeypox Virus

, 2011
Smallpox preparedness research has led to development of antiviral therapies for treatment of serious orthopoxvirus infections. Monkeypox virus is an emerging, zoonotic orthopoxvirus which can cause severe and transmissible disease in humans, generating ...
Scott K. Smith, Robert Jordan, Sonja Weiss, Zach Braden, Russell L. Regnery, Dennis E. Hruby, Josh Self, Inger K. Damon, Darin Carroll, Whitni Davidson   +9 more
core   +1 more source

A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection

Molecular Therapy: Oncolytics, 2018
This study hypothesizes that a novel oncolytic chimeric orthopoxvirus CF33-Fluc is imageable and targets colorectal cancer cells (CRCs). A novel chimeric orthopoxvirus (CF33) was constructed.
M. O'Leary, S. Warner, Sang-In Kim, S. Chaurasiya, Jianming Lu, A. Choi, Anthony K. Park, Y. Woo, Y. Fong, N. Chen   +9 more
semanticscholar   +1 more source