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Mpox Epidemics: A Call to Restore Humanity’s Lost Herd Immunity to Orthopoxviruses [PDF]
VirusesGlobal efforts to eradicate smallpox—an Orthopoxvirus infection—began in the mid-20th century, with the last naturally occurring case reported in 1977. This was achieved through global solidarity efforts that expanded the smallpox eradication vaccination
Misaki Wayengera +11 more
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Problems of Virology, 2019 Introduction. The abolition of smallpox vaccination has led to the disappearance of population immunity to pox viruses. However, the threat of infection by pathogenic orthopoxviruses persists and determines the need to develop sensitive and operational ...
Pavel V Filatov +2 more
exaly +3 more sources
Monkeypox: A Global Challenge [PDF]
Liaquat National Journal of Primary Care, 2022 Monkeypox has emerged as the most significant human pathogen in recent times and is a rapidly growing threat to public health globally. Monkeypox virus is an orthopoxvirus, that belongs to the Poxviridae family.
Sannia Perwaiz Iqbal, Sajid Abbas Jaffri
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An Update of Orthopoxvirus Molecular Evolution
Viruses, 2022 Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete ...
Igor V. Babkin +2 more
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Viruses, 2020 The global emergence of zoonotic viruses, including poxviruses, poses one of the greatest threats to human and animal health. Forty years after the eradication of smallpox, emerging zoonotic orthopoxviruses, such as monkeypox, cowpox, and vaccinia ...
Natalia Ingrid Oliveira Silva +4 more
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Viruses, 2023 Background: Since most of the modern human population has no anti-smallpox immunity, it is extremely important to develop and implement effective drugs for the treatment of smallpox and other orthopoxvirus infections.
Larisa N. Shishkina +16 more
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Evolution of means and principles of smallpox vaccination
Вестник войск РХБ защиты, 2020 There are several possible reasons for the return of smallpox as an endemic disease. For example, the possibility of maintaining smallpox virus in an active state in the corpses of the dead, buried in permafrost regions, or the evolutionary changes of ...
S. V. Borisevich +7 more
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Detection of North American orthopoxviruses by real time-PCR
Virology Journal, 2011 The prevalence of North American orthopoxviruses in nature is unknown and may be more difficult to ascertain due to wide spread use of vaccinia virus recombinant vaccines in the wild.
Damon Inger K +9 more
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Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization
Microbiology Spectrum, 2023 Members of the Orthopoxvirus genus can cause severe infections in humans. Global vaccination against smallpox, caused by the variola virus, resulted in the eradication of the disease in 1980.
Tal Noy-Porat +15 more
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Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses
Viruses, 2010 The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with ...
Mark N. Prichard, Earl R. Kern
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