Serologic evidence of human orthopoxvirus infections in Sierra Leone [PDF]
BMC Research Notes, 2011 Background Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986.
Goba Augustine +12 more
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Rapid Detection of Orthopoxviruses [PDF]
Проблемы особо опасных инфекций, 2021 The aim of the study was to develop a sensitive and fast immunochemical test for the detection of orthopoxviruses (OPXV) in the “point of care” format.Materials and methods.
A. G. Poltavchenko +6 more
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Different immunogens and prime-boost vaccination strategies affect the efficacy of recombinant candidate vaccines against pathogenic orthopoxviruses [PDF]
Virology JournalHighlights Recombinant avipoxviruses as putative recombinant vaccines against MPXV. Different prime–boost regimens to improve immunization against orthopoxviruses.
Antonia Radaelli +8 more
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The French Armed Forces Virology Unit: A Chronological Record of Ongoing Research on Orthopoxvirus
Viruses, 2017 Since the official declaration of smallpox eradication in 1980, the general population vaccination has ceased worldwide. Therefore, people under 40 year old are generally not vaccinated against smallpox and have no cross protection against orthopoxvirus ...
Déborah Delaune +4 more
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A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa [PDF]
Viruses, 2017 Since the eradication of smallpox and the subsequent discontinuation of the worldwide smallpox vaccination program, other Orthopoxviruses beside Variola virus have been increasingly representing a risk to human health.
Siv Aina J. Leendertz +14 more
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Smallpox, Monkeypox and Other Human Orthopoxvirus Infections
Viruses, 2022 Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all ...
Galina A. Shchelkunova +1 more
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Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening. [PDF]
Biotechnol JGraphical Abstract and Lay Summary By combining interspecies protein analysis with advanced virtual screening, this study identifies potent repurposed drug candidates—including vindesine and LY2090314—targeting mpox DNA topoisomerase and polymerase. This workflow provides a rapid, practical framework for antiviral discovery against emerging infectious ...
Yu T, Jang WD, Lee SY.
europepmc +2 more sources
A Global Health Alert on the Re-Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review. [PDF]
Health Sci RepABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Aqeel MB +6 more
europepmc +2 more sources
EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxviruses
, 2023 EPIPOX is a specialized online resource intended to facilitate the design of epitope-based vaccines against orthopoxviruses. EPIPOX is built upon a collection of T cell epitopes that are shared by eight pathogenic orthopoxviruses, including variola minor
Peláez Prestel, Héctor Fernando +7 more
core +2 more sources
Portable molecular diagnostic platform for rapid point-of-care detection of mpox and other diseases [PDF]
Nature CommunicationsThe World Health Organization’s designation of mpox as a public health emergency of international concern in August 2024 underscores the urgent need for effective diagnostic solutions to combat this escalating threat.
Matthew L. Cavuto +21 more
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